Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2007-5-8
pubmed:abstractText
Hepatic steatosis occurs frequently in patients with chronic hepatitis B virus (HBV) or chronic hepatitis C virus (HCV) infection. Recently, several studies suggested that steatosis plays an important role as a cofactor in other liver diseases such as hepatic fibrosis, hepatitis, and liver cancer. In contrast to HCV, however, the molecular mechanism by which HBV mediates hepatic steatosis has not been clearly studied. Here, we show the molecular mechanism by which hepatitis B virus X protein (HBx) induces hepatic steatosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0016-5085
pubmed:author
pubmed:issnType
Print
pubmed:volume
132
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1955-67
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:17484888-Acetyl-CoA Carboxylase, pubmed-meshheading:17484888-Animals, pubmed-meshheading:17484888-Cell Line, pubmed-meshheading:17484888-Cell Line, Tumor, pubmed-meshheading:17484888-Disease Progression, pubmed-meshheading:17484888-Fatty Liver, pubmed-meshheading:17484888-Gene Expression Regulation, pubmed-meshheading:17484888-Hepatitis B virus, pubmed-meshheading:17484888-Humans, pubmed-meshheading:17484888-Lipid Metabolism, pubmed-meshheading:17484888-Mice, pubmed-meshheading:17484888-Mice, Inbred C57BL, pubmed-meshheading:17484888-Mice, Inbred CBA, pubmed-meshheading:17484888-Mice, Transgenic, pubmed-meshheading:17484888-PPAR gamma, pubmed-meshheading:17484888-Phosphatidylinositol 3-Kinases, pubmed-meshheading:17484888-Stearoyl-CoA Desaturase, pubmed-meshheading:17484888-Sterol Regulatory Element Binding Protein 1, pubmed-meshheading:17484888-Trans-Activators, pubmed-meshheading:17484888-Transcription, Genetic, pubmed-meshheading:17484888-Transfection
pubmed:year
2007
pubmed:articleTitle
Hepatitis B virus X protein induces hepatic steatosis via transcriptional activation of SREBP1 and PPARgamma.
pubmed:affiliation
Department of Molecular Biology, Pusan National University, Busan, Korea.
pubmed:publicationType
Journal Article