rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
5
|
pubmed:dateCreated |
2007-5-8
|
pubmed:abstractText |
Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive triglyceride accumulation in hepatocytes. Expression of the lipid droplet protein adipose differentiation-related protein (ADRP) is increased in NAFLD, but whether this is causally linked to hepatic lipid metabolism is unclear. We postulated that a reduction in ADRP would ameliorate hepatic steatosis and improve insulin action.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
0016-5085
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
132
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1947-54
|
pubmed:dateRevised |
2011-10-18
|
pubmed:meshHeading |
pubmed-meshheading:17484887-Alanine Transaminase,
pubmed-meshheading:17484887-Animals,
pubmed-meshheading:17484887-Fatty Liver,
pubmed-meshheading:17484887-Female,
pubmed-meshheading:17484887-Gene Expression Regulation,
pubmed-meshheading:17484887-Hypertriglyceridemia,
pubmed-meshheading:17484887-Insulin Resistance,
pubmed-meshheading:17484887-Lipid Metabolism,
pubmed-meshheading:17484887-Liver,
pubmed-meshheading:17484887-Membrane Proteins,
pubmed-meshheading:17484887-Mice,
pubmed-meshheading:17484887-Mice, Inbred C57BL,
pubmed-meshheading:17484887-Obesity,
pubmed-meshheading:17484887-Oligoribonucleotides, Antisense,
pubmed-meshheading:17484887-RNA, Messenger
|
pubmed:year |
2007
|
pubmed:articleTitle |
Reduction of hepatosteatosis and lipid levels by an adipose differentiation-related protein antisense oligonucleotide.
|
pubmed:affiliation |
Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19010, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|