rdf:type |
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lifeskim:mentions |
|
pubmed:issue |
5
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pubmed:dateCreated |
2007-5-8
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pubmed:abstractText |
It has been generally assumed that interstitial cells of Cajal (ICC) in the human gastrointestinal tract have similar functions to those in rodents, but no direct experimental evidence exists to date for this assumption. This is an important question because pathologists have noted decreased numbers of ICC in patients with a variety of motility disorders, and some have speculated that loss of ICC could be responsible for motor dysfunction. Our aims were to determine whether myenteric ICC (ICC-MY) in human jejunum are pacemaker cells and whether these cells actively propagate pacemaker activity.
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pubmed:grant |
|
pubmed:commentsCorrections |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
0016-5085
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pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
132
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1852-65
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:17484879-Adult,
pubmed-meshheading:17484879-Biological Clocks,
pubmed-meshheading:17484879-Caffeine,
pubmed-meshheading:17484879-Calcium,
pubmed-meshheading:17484879-Calcium Channel Blockers,
pubmed-meshheading:17484879-Central Nervous System Stimulants,
pubmed-meshheading:17484879-Electrophysiology,
pubmed-meshheading:17484879-Female,
pubmed-meshheading:17484879-Humans,
pubmed-meshheading:17484879-Inositol 1,4,5-Trisphosphate Receptors,
pubmed-meshheading:17484879-Intestinal Mucosa,
pubmed-meshheading:17484879-Jejunum,
pubmed-meshheading:17484879-Male,
pubmed-meshheading:17484879-Middle Aged,
pubmed-meshheading:17484879-Myenteric Plexus,
pubmed-meshheading:17484879-Myocytes, Smooth Muscle,
pubmed-meshheading:17484879-Nicardipine
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pubmed:year |
2007
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pubmed:articleTitle |
The mechanism and spread of pacemaker activity through myenteric interstitial cells of Cajal in human small intestine.
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pubmed:affiliation |
Department of Physiology & Cell Biology, University of Nevada School of Medicine, Reno, Nevada 89577, USA.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, N.I.H., Extramural
|