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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2007-5-8
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pubmed:abstractText |
We recently identified lysophosphatidic acid (LPA) as a potent antiapoptotic agent for the intestinal epithelium. The objective of the present study was to evaluate the effect of octadecenyl thiophosphate (OTP), a novel rationally designed, metabolically stabilized LPA mimic, on radiation-induced apoptosis of intestinal epithelial cells in vitro and in vivo.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0016-5085
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pubmed:author |
pubmed-author:ArsuraMarcelloM,
pubmed-author:BalazsLouisaL,
pubmed-author:DengWenlinW,
pubmed-author:DurgamGangadharG,
pubmed-author:EShuyuS,
pubmed-author:GududuruVeeresaV,
pubmed-author:JohnsonLeonard RLR,
pubmed-author:MillerDuane DDD,
pubmed-author:ParrillAbby LAL,
pubmed-author:TigyiGaborG,
pubmed-author:TsukaharaRyokoR,
pubmed-author:ValentineWilliam JWJ,
pubmed-author:VanMiddlesworthLesterL,
pubmed-author:VenkatramanManickamM
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pubmed:issnType |
Print
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pubmed:volume |
132
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1834-51
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pubmed:dateRevised |
2011-4-26
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pubmed:meshHeading |
pubmed-meshheading:17484878-Administration, Oral,
pubmed-meshheading:17484878-Animals,
pubmed-meshheading:17484878-Apoptosis,
pubmed-meshheading:17484878-Cell Line,
pubmed-meshheading:17484878-Cells, Cultured,
pubmed-meshheading:17484878-Dose-Response Relationship, Drug,
pubmed-meshheading:17484878-Female,
pubmed-meshheading:17484878-GTP-Binding Proteins,
pubmed-meshheading:17484878-Gamma Rays,
pubmed-meshheading:17484878-Gene Expression Regulation,
pubmed-meshheading:17484878-Injections, Intraperitoneal,
pubmed-meshheading:17484878-Intestinal Mucosa,
pubmed-meshheading:17484878-Mice,
pubmed-meshheading:17484878-Mice, Inbred C57BL,
pubmed-meshheading:17484878-Mice, Knockout,
pubmed-meshheading:17484878-Mitogen-Activated Protein Kinases,
pubmed-meshheading:17484878-Nerve Tissue Proteins,
pubmed-meshheading:17484878-Organophosphorus Compounds,
pubmed-meshheading:17484878-Phosphatidylinositol 3-Kinases,
pubmed-meshheading:17484878-Radiation Injuries, Experimental,
pubmed-meshheading:17484878-Receptors, Lysophosphatidic Acid,
pubmed-meshheading:17484878-Signal Transduction,
pubmed-meshheading:17484878-Tumor Necrosis Factor-alpha
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pubmed:year |
2007
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pubmed:articleTitle |
The lysophosphatidic acid type 2 receptor is required for protection against radiation-induced intestinal injury.
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pubmed:affiliation |
Department of Physiology, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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