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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1992-1-21
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pubmed:abstractText |
We studied the mechanisms of action leading to the glucocorticoid (GC)-induced synthesis of the immunoglobulins (IgE, G, A, M) by human peripheral blood mononuclear cells (PBMC). It is shown that the enhanced Ig synthesis of GC-stimulated PBMC is dependent on the presence of T cells and monocytes. After stimulation of purified B cells with GC only a slight enhancement of IgM could be detected. Inhibition studies with neutralizing anti-interleukin-4 (IL-4) and anti-IL-6 antibodies revealed that the GC-induced IgE synthesis of PBMC is not dependent on the presence of IL-4 or IL-6. Stimulation of membrane-separated and co-cultured cell fractions revealed that the GC-induced enhancement of IgA and IgM synthesis is mediated by T-cell derived soluble mediators. The GC-induced IgG and IgE synthesis is dependent upon contact of B cells with monocytes. Antibodies against LFA-1 and ICAM-1 are capable to suppress the GC-induced IgE and IgG synthesis of PBMC. Furthermore, the monocyte expression of lymphocyte function antigen-1 (LFA-1), intercellular adhesion molecule-1 (ICAM-1) and HLA-DR is modulated by GC stimulation.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1748471-1825666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1748471-2138194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1748471-2149121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1748471-2478656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1748471-2522501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1748471-2606141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1748471-2789139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1748471-2931480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1748471-2969398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1748471-3109924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1748471-3257219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1748471-3362863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1748471-3918092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1748471-5305881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1748471-6206141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1748471-6214495,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1748471-6427338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1748471-65435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1748471-7033287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1748471-712020,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1748471-96133
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
228-33
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1748471-B-Lymphocytes,
pubmed-meshheading:1748471-Cell Adhesion Molecules,
pubmed-meshheading:1748471-Cells, Cultured,
pubmed-meshheading:1748471-Humans,
pubmed-meshheading:1748471-Immunoglobulin E,
pubmed-meshheading:1748471-Immunoglobulins,
pubmed-meshheading:1748471-Interleukin-4,
pubmed-meshheading:1748471-Interleukin-6,
pubmed-meshheading:1748471-Interleukins,
pubmed-meshheading:1748471-Leukocytes, Mononuclear,
pubmed-meshheading:1748471-Monocytes,
pubmed-meshheading:1748471-Prednisolone,
pubmed-meshheading:1748471-T-Lymphocytes
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pubmed:year |
1991
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pubmed:articleTitle |
Influence of cytokines and cellular interactions on the glucocorticoid-induced Ig (E, G, A, M) synthesis of peripheral blood mononuclear cells.
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pubmed:affiliation |
Medizinische Mikrobiologie und Immunologie, AG Infektabwehr, Bochum, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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