| pubmed-article:17483470 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17483470 | lifeskim:mentions | umls-concept:C0025936 | lld:lifeskim |
| pubmed-article:17483470 | lifeskim:mentions | umls-concept:C1178983 | lld:lifeskim |
| pubmed-article:17483470 | lifeskim:mentions | umls-concept:C1283195 | lld:lifeskim |
| pubmed-article:17483470 | pubmed:issue | 19 | lld:pubmed |
| pubmed-article:17483470 | pubmed:dateCreated | 2007-5-9 | lld:pubmed |
| pubmed-article:17483470 | pubmed:abstractText | To permit rapid optical control of brain activity, we have engineered multiple lines of transgenic mice that express the light-activated cation channel Channelrhodopsin-2 (ChR2) in subsets of neurons. Illumination of ChR2-positive neurons in brain slices produced photocurrents that generated action potentials within milliseconds and with precisely timed latencies. The number of light-evoked action potentials could be controlled by varying either the amplitude or duration of illumination. Furthermore, the frequency of light-evoked action potentials could be precisely controlled up to 30 Hz. Photostimulation also could evoke synaptic transmission between neurons, and, by scanning with a small laser light spot, we were able to map the spatial distribution of synaptic circuits connecting neurons within living cerebral cortex. We conclude that ChR2 is a genetically based photostimulation technology that permits analysis of neural circuits with high spatial and temporal resolution in transgenic mammals. | lld:pubmed |
| pubmed-article:17483470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17483470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17483470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17483470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17483470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17483470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17483470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17483470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17483470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17483470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17483470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17483470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17483470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17483470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17483470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17483470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17483470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17483470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17483470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17483470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17483470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17483470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17483470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17483470 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17483470 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17483470 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17483470 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17483470 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17483470 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17483470 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17483470 | pubmed:month | May | lld:pubmed |
| pubmed-article:17483470 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:17483470 | pubmed:author | pubmed-author:MatsuzakiMM | lld:pubmed |
| pubmed-article:17483470 | pubmed:author | pubmed-author:NoguchiJJ | lld:pubmed |
| pubmed-article:17483470 | pubmed:author | pubmed-author:WangDD | lld:pubmed |
| pubmed-article:17483470 | pubmed:author | pubmed-author:KasaiHH | lld:pubmed |
| pubmed-article:17483470 | pubmed:author | pubmed-author:HallW CWC | lld:pubmed |
| pubmed-article:17483470 | pubmed:author | pubmed-author:WangHH | lld:pubmed |
| pubmed-article:17483470 | pubmed:author | pubmed-author:PeckDD | lld:pubmed |
| pubmed-article:17483470 | pubmed:author | pubmed-author:MatsuzakiKK | lld:pubmed |
| pubmed-article:17483470 | pubmed:author | pubmed-author:ZhangFF | lld:pubmed |
| pubmed-article:17483470 | pubmed:author | pubmed-author:AugustineG... | lld:pubmed |
| pubmed-article:17483470 | pubmed:author | pubmed-author:QiuLL | lld:pubmed |
| pubmed-article:17483470 | pubmed:author | pubmed-author:DeisserothKK | lld:pubmed |
| pubmed-article:17483470 | pubmed:author | pubmed-author:FendJJ | lld:pubmed |
| pubmed-article:17483470 | pubmed:author | pubmed-author:BoydenEE | lld:pubmed |
| pubmed-article:17483470 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17483470 | pubmed:day | 8 | lld:pubmed |
| pubmed-article:17483470 | pubmed:volume | 104 | lld:pubmed |
| pubmed-article:17483470 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17483470 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17483470 | pubmed:pagination | 8143-8 | lld:pubmed |
| pubmed-article:17483470 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:17483470 | pubmed:meshHeading | pubmed-meshheading:17483470... | lld:pubmed |
| pubmed-article:17483470 | pubmed:meshHeading | pubmed-meshheading:17483470... | lld:pubmed |
| pubmed-article:17483470 | pubmed:meshHeading | pubmed-meshheading:17483470... | lld:pubmed |
| pubmed-article:17483470 | pubmed:meshHeading | pubmed-meshheading:17483470... | lld:pubmed |
| pubmed-article:17483470 | pubmed:meshHeading | pubmed-meshheading:17483470... | lld:pubmed |
| pubmed-article:17483470 | pubmed:meshHeading | pubmed-meshheading:17483470... | lld:pubmed |
| pubmed-article:17483470 | pubmed:meshHeading | pubmed-meshheading:17483470... | lld:pubmed |
| pubmed-article:17483470 | pubmed:meshHeading | pubmed-meshheading:17483470... | lld:pubmed |
| pubmed-article:17483470 | pubmed:meshHeading | pubmed-meshheading:17483470... | lld:pubmed |
| pubmed-article:17483470 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17483470 | pubmed:articleTitle | High-speed mapping of synaptic connectivity using photostimulation in Channelrhodopsin-2 transgenic mice. | lld:pubmed |
| pubmed-article:17483470 | pubmed:affiliation | Department of Neurobiology, Duke University, Durham, NC 27710, USA. | lld:pubmed |
| pubmed-article:17483470 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17483470 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17483470 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17483470 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17483470 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17483470 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17483470 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17483470 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17483470 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17483470 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17483470 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17483470 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17483470 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17483470 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17483470 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17483470 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17483470 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17483470 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17483470 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17483470 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17483470 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17483470 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17483470 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17483470 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17483470 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17483470 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17483470 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17483470 | lld:pubmed |
