Source:http://linkedlifedata.com/resource/pubmed/id/17483295
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2007-8-6
|
| pubmed:abstractText |
Very low-dose irradiation (2 x 2 Gy) is a new, effective, and safe local treatment for follicular lymphoma. To understand the biologic mechanisms of this extremely effective response, we compared by microarray the gene-expression profile of patients' biopsies taken before and after radiation. In all patients, a major and consistent induction of p53 target genes was seen. p53 targets involved in cell-cycle arrest and apoptosis showed the same mode of regulation, indicating that, in vivo, both are activated simultaneously. p53 up-regulation and p53-mediated proliferation arrest and apoptosis were substantiated using immunohistochemistry, with activation of both the intrinsic and the extrinsic apoptotic pathways. The other induced genes revealed a whole set of biologically meaningful genes related to macrophage activation and TH1 immune response. Immunohistochemical analysis suggested a specific activation or differentiation of resident macrophages by apoptotic cells. These biologic insights are important arguments to advocate the use of low-dose radiotherapy as an effective palliative treatment for follicular lymphoma. Moreover, this study is the first in vivo report of the radiation-induced p53 apoptotic response in patients and suggests that this apoptotic response is not immunologically silent.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0006-4971
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| pubmed:author |
pubmed-author:BroeksAnnegienA,
pubmed-author:ElderingEricE,
pubmed-author:HaasRickR,
pubmed-author:KnoopsLaurentL,
pubmed-author:MajoorDonnéD,
pubmed-author:VerheijMarcelM,
pubmed-author:de BoerJan PaulJP,
pubmed-author:de JongDaphneD,
pubmed-author:de KempSanneS,
pubmed-author:de VriesAnnemiekeA,
pubmed-author:van't VeerLauraL,
pubmed-author:van OstromConnyC
|
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
110
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1116-22
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:17483295-Adult,
pubmed-meshheading:17483295-Aged,
pubmed-meshheading:17483295-Aged, 80 and over,
pubmed-meshheading:17483295-Apoptosis,
pubmed-meshheading:17483295-Female,
pubmed-meshheading:17483295-Gamma Rays,
pubmed-meshheading:17483295-Gene Expression Profiling,
pubmed-meshheading:17483295-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:17483295-Humans,
pubmed-meshheading:17483295-Immunoenzyme Techniques,
pubmed-meshheading:17483295-Lymphoma, B-Cell,
pubmed-meshheading:17483295-Lymphoma, Follicular,
pubmed-meshheading:17483295-Lymphoma, Large B-Cell, Diffuse,
pubmed-meshheading:17483295-Male,
pubmed-meshheading:17483295-Middle Aged,
pubmed-meshheading:17483295-Mutation,
pubmed-meshheading:17483295-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:17483295-RNA, Messenger,
pubmed-meshheading:17483295-Tumor Suppressor Protein p53
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
In vivo p53 response and immune reaction underlie highly effective low-dose radiotherapy in follicular lymphoma.
|
| pubmed:affiliation |
Department of Pathology, The Netherlands Cancer Institute, Amsterdam, the Netherlands.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|