Linked Life Data

17482957

Source:http://linkedlifedata.com/resource/pubmed/id/17482957

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2007-5-7
pubmed:abstractText
Thymidylate synthase (TS), a key enzyme in DNA synthesis, is overexpressed in a variety of cancer cells. 5-Fluorouracil (5-FU), an anticancer agent used clinically against various cancers, including prostate cancer, inhibits DNA synthesis by binding TS. In this study, we investigated the expression of TS in prostate cancer and its prognostic significance. Its association with the expression of dihydropyrimidine dehydrogenase (DPD), a principal enzyme in the degradation of 5-FU and pyrimidine nucleotides, was also examined.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1527-9995
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
69
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
988-95
pubmed:meshHeading
pubmed-meshheading:17482957-Aged, pubmed-meshheading:17482957-Biopsy, Needle, pubmed-meshheading:17482957-Chi-Square Distribution, pubmed-meshheading:17482957-Humans, pubmed-meshheading:17482957-Immunohistochemistry, pubmed-meshheading:17482957-Incidence, pubmed-meshheading:17482957-Male, pubmed-meshheading:17482957-Middle Aged, pubmed-meshheading:17482957-Neoplasm Recurrence, Local, pubmed-meshheading:17482957-Neoplasm Staging, pubmed-meshheading:17482957-Probability, pubmed-meshheading:17482957-Prognosis, pubmed-meshheading:17482957-Proportional Hazards Models, pubmed-meshheading:17482957-Prostatectomy, pubmed-meshheading:17482957-Prostatic Neoplasms, pubmed-meshheading:17482957-Reference Values, pubmed-meshheading:17482957-Retrospective Studies, pubmed-meshheading:17482957-Risk Assessment, pubmed-meshheading:17482957-Sampling Studies, pubmed-meshheading:17482957-Thymidylate Synthase, pubmed-meshheading:17482957-Treatment Outcome, pubmed-meshheading:17482957-Tumor Markers, Biological
pubmed:year
2007
pubmed:articleTitle
Prognostic significance of thymidylate synthase expression in patients with prostate cancer undergoing radical prostatectomy.
pubmed:affiliation
Department of Urology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't