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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
2007-5-28
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pubmed:abstractText |
We describe herein the isolation and semisynthesis of four acetogenin derivatives (1-4) as well as their ability to inhibit the mitochondrial respiratory chain and several tumor cell lines. In addition, four nanoseconds (ns) of MD simulation of compound 4, in a fully hydrated POPC bilayer, is reported.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0968-0896
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pubmed:author |
pubmed-author:BaldoniHéctor AHA,
pubmed-author:BarrachinaIsabelI,
pubmed-author:BermejoAlmudenaA,
pubmed-author:CabedoNuriaN,
pubmed-author:ChahbouneNadiaN,
pubmed-author:CortesDiegoD,
pubmed-author:DePedroNuriaN,
pubmed-author:El AouadNoureddineN,
pubmed-author:EnrizRicardo DRD,
pubmed-author:RoyoInmaculadaI,
pubmed-author:SaezJairoJ,
pubmed-author:SuvireFernandoF,
pubmed-author:TormoJosé RJR,
pubmed-author:Zafra-PoloM CarmenMC
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4369-81
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:17482824-Acetogenins,
pubmed-meshheading:17482824-Annona,
pubmed-meshheading:17482824-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:17482824-Cell Line, Tumor,
pubmed-meshheading:17482824-Computer Simulation,
pubmed-meshheading:17482824-Electron Transport,
pubmed-meshheading:17482824-Fatty Alcohols,
pubmed-meshheading:17482824-Furans,
pubmed-meshheading:17482824-Humans,
pubmed-meshheading:17482824-Hydrogen Bonding,
pubmed-meshheading:17482824-Indicators and Reagents,
pubmed-meshheading:17482824-Lactones,
pubmed-meshheading:17482824-Lipid Bilayers,
pubmed-meshheading:17482824-Magnetic Resonance Spectroscopy,
pubmed-meshheading:17482824-Models, Molecular,
pubmed-meshheading:17482824-Molecular Conformation,
pubmed-meshheading:17482824-Phosphatidylcholines,
pubmed-meshheading:17482824-Seeds
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pubmed:year |
2007
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pubmed:articleTitle |
New antitumoral acetogenin 'Guanacone type' derivatives: isolation and bioactivity. Molecular dynamics simulation of diacetyl-guanacone.
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pubmed:affiliation |
Departamento de Farmacología, Facultad de Farmacia, Universidad de Valencia, 46100 Burjassot, Valencia, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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