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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
13
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pubmed:dateCreated |
2007-6-18
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pubmed:abstractText |
Fifty-two C-glycosides were synthesized and their in-vitro antiproliferative activity screened against human cervical carcinoma (HeLa) and osteosarcoma (HOS) cell lines. Nine of them had growth inhibitions (GI(50) values) below 10 microM, the C-glucopyranoside 38 being the most active against HeLa (5.4 microM) and the dichlorocyclopropyl derivative 42 against HOS (1.6 microM). Some preliminary structure-activity relationships were established.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3676-81
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pubmed:meshHeading |
pubmed-meshheading:17482817-Antineoplastic Agents,
pubmed-meshheading:17482817-Bone Neoplasms,
pubmed-meshheading:17482817-Cell Line, Tumor,
pubmed-meshheading:17482817-Cell Proliferation,
pubmed-meshheading:17482817-Drug Screening Assays, Antitumor,
pubmed-meshheading:17482817-Glycosides,
pubmed-meshheading:17482817-HeLa Cells,
pubmed-meshheading:17482817-Humans,
pubmed-meshheading:17482817-Inhibitory Concentration 50,
pubmed-meshheading:17482817-Models, Chemical,
pubmed-meshheading:17482817-Osteosarcoma,
pubmed-meshheading:17482817-Stereoisomerism,
pubmed-meshheading:17482817-Structure-Activity Relationship
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pubmed:year |
2007
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pubmed:articleTitle |
Cytotoxic effects of C-glycosides in HOS and HeLa cell lines.
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pubmed:affiliation |
Instituto Universitario de Bio-Orgánica Antonio González, Departamento de Química Orgánica, Universidad de La Laguna, La Laguna, Tenerife, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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