Linked Life Data

17482447

Source:http://linkedlifedata.com/resource/pubmed/id/17482447

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2008-2-18
pubmed:abstractText
In vitro effects of arsenic in human peripheral lymphocytes (HPL) at three different doses - 3.6x10(-4), 1.4 x 10(-3) and 0.72 x 10(-3) microM for 24h before harvesting on sister chromatid exchanges (SCE), Cell cycle proliferative index/replicative index (CCPI/RI), %M(1), %M(2) and %M(3), population doubling time (PDT) and average generation time (AGT) were examined. Andrographis paniculata (commonly referred to as 'kalmegh') has been used for centuries in traditional Indian and Chinese herbal medicine as a safe, natural folk remedy for assorted health concerns. In the present study, kalmegh (0.01 microg/7ml culture media) was used along with the highest dose of arsenic; the results showed that arsenic induced increase in these genotoxic endpoints were fairly diminished by kalmegh. In addition, mutagenic in vitro effect of ethyl methanesulphonate (EMS) was used as a positive control in this study. It is thus concluded from this study that Andrographis has a protective role in arsenic toxicity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1618-095X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
221-5
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
In vitro cytogenetic effects of Andrographis paniculata (kalmegh) on arsenic.
pubmed:affiliation
Department of Zoology, University School of Sciences, Gujarat University, Navrangpura, Ahmedabad 380 009, Gujarat, India. avanigopalkrishnan@yahoo.com
pubmed:publicationType
Journal Article