Source:http://linkedlifedata.com/resource/pubmed/id/17481608
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2007-6-25
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| pubmed:abstractText |
Circumstantial evidence has suggested that activated microglia may be associated with the pathogenesis of depression. Pro-inflammatory cytokines may also be involved. Therefore, we examined the effects of various types of antidepressants, as well as the mood-stabilizer lithium chloride, on interferon-gamma (IFN-gamma)-induced microglial production of the pro-inflammatory mediators interleukin-6 (IL-6) and nitric oxide (NO). Treatment of the murine microglial 6-3 cells with 100 U/ml of IFN-gamma resulted in an eightfold increase in IL-6 and a tenfold increase in NO into the culture medium. Pretreatment with the selective serotonin reuptake inhibitor fluvoxamine, the relatively selective noradrenaline reuptake inhibitor reboxetine, or the non-selective monoaminergic reuptake inhibitor imipramine, significantly inhibited IL-6 and NO production in a dose-dependent manner. These inhibitions were reversed significantly by SQ 22536, a cyclic adenosine monophosphate (cAMP) inhibitor, and, except for reboxetine, by the protein kinase A (PKA) inhibitor Rp-adenosine3',5'-cyclic monophosphorothioate triethylammonium salt (Rp-3',5'-cAMPS). Lithium chloride, which is believed to act by inhibiting the calcium-dependent release of noradrenaline, had a different spectrum of action on microglial 6-3 cells. It enhanced IFN-gamma-stimulated IL-6 production and inhibited NO production. The inhibitory effect of lithium chloride was not reversed by either SQ 22536 or Rp-3',5'-cAMPS. These results suggest that antidepressants have inhibitory effects on IFN-gamma-activated microglia and these effects are, at least partially, mediated by the cAMP-dependent PKA pathway. On the other hand, the mood stabilizer and anti-manic agent lithium chloride has mixed effects on IFN-gamma-induced microglial activation.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antidepressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antimanic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antiviral Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP-Dependent Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP-Dependent Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Lithium Chloride,
http://linkedlifedata.com/resource/pubmed/chemical/Neurotransmitter Uptake Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
0014-4886
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
206
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
33-42
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:17481608-Animals,
pubmed-meshheading:17481608-Antidepressive Agents,
pubmed-meshheading:17481608-Antimanic Agents,
pubmed-meshheading:17481608-Antiviral Agents,
pubmed-meshheading:17481608-Brain,
pubmed-meshheading:17481608-Cell Line,
pubmed-meshheading:17481608-Cyclic AMP,
pubmed-meshheading:17481608-Cyclic AMP-Dependent Protein Kinase Type II,
pubmed-meshheading:17481608-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:17481608-Depressive Disorder,
pubmed-meshheading:17481608-Dose-Response Relationship, Drug,
pubmed-meshheading:17481608-Enzyme Inhibitors,
pubmed-meshheading:17481608-Interferon-gamma,
pubmed-meshheading:17481608-Interleukin-6,
pubmed-meshheading:17481608-Lithium Chloride,
pubmed-meshheading:17481608-MAP Kinase Signaling System,
pubmed-meshheading:17481608-Mice,
pubmed-meshheading:17481608-Mice, Inbred C57BL,
pubmed-meshheading:17481608-Microglia,
pubmed-meshheading:17481608-Neurotransmitter Uptake Inhibitors,
pubmed-meshheading:17481608-Nitric Oxide,
pubmed-meshheading:17481608-Up-Regulation
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| pubmed:year |
2007
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| pubmed:articleTitle |
Antidepressants inhibit interferon-gamma-induced microglial production of IL-6 and nitric oxide.
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| pubmed:affiliation |
Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, 812-8582 Japan. hashioka@interchange.ubc.ca
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| pubmed:publicationType |
Journal Article
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