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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2007-5-7
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pubmed:abstractText |
The pyrethroid knockdown resistance gene (kdr) has become widespread in Anopheles gambiae in West Africa. A trial to test the continuing efficacy of insecticide-treated nets (ITN) and indoor residual spraying (IRS) was undertaken in experimental huts at 2 sites in Benin, the first where kdr is present at high frequency (Ladji), the second-where An. gambiae is susceptible (Malanville). Holes were made in the nets to mimic worn nets. At Malanville, 96% of susceptible An. gambiae were inhibited from blood-feeding, whereas at Ladji feeding was uninhibited by ITNs. The mortality rate of An. gambiae in ITN huts was 98% in Malanville but only 30% at Ladji. The efficacy of IRS was equally compromised. Mosquitoes at Ladji had higher oxidase and esterase activity than in a laboratory-susceptible strain, but this fact did not seem to contribute to resistance. Pyrethroid resistance in An. gambiae appears to threaten the future of ITN and IRS in Benin.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17479880-10212513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17479880-10342269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17479880-10399604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17479880-10863621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17479880-10872862,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17479880-10948372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17479880-11029667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17479880-11297094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17479880-11297108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17479880-12460390,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17479880-12749501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17479880-14704095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17479880-15189238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17479880-15242513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17479880-15303988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17479880-15569394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17479880-15918909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17479880-16282294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17479880-16820067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17479880-9535162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17479880-9735932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17479880-9737593
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1080-6040
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
199-206
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17479880-Animals,
pubmed-meshheading:17479880-Anopheles gambiae,
pubmed-meshheading:17479880-Bedding and Linens,
pubmed-meshheading:17479880-Benin,
pubmed-meshheading:17479880-Culex,
pubmed-meshheading:17479880-Humans,
pubmed-meshheading:17479880-Insecticide Resistance,
pubmed-meshheading:17479880-Insecticides,
pubmed-meshheading:17479880-Malaria,
pubmed-meshheading:17479880-Mosquito Control,
pubmed-meshheading:17479880-Nitriles,
pubmed-meshheading:17479880-Pyrethrins
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pubmed:year |
2007
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pubmed:articleTitle |
Reduced efficacy of insecticide-treated nets and indoor residual spraying for malaria control in pyrethroid resistance area, Benin.
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pubmed:affiliation |
London School of Hygiene and Tropical Medicine, Cotonou, Benin, West Africa.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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