| pubmed-article:1747960 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1747960 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:1747960 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:1747960 | lifeskim:mentions | umls-concept:C0023828 | lld:lifeskim |
| pubmed-article:1747960 | lifeskim:mentions | umls-concept:C0040691 | lld:lifeskim |
| pubmed-article:1747960 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:1747960 | lifeskim:mentions | umls-concept:C0443286 | lld:lifeskim |
| pubmed-article:1747960 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:1747960 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:1747960 | lifeskim:mentions | umls-concept:C0439662 | lld:lifeskim |
| pubmed-article:1747960 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:1747960 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1747960 | pubmed:dateCreated | 1992-1-21 | lld:pubmed |
| pubmed-article:1747960 | pubmed:abstractText | In view of its potent inhibitory capacity on immune cells in culture, we wished to determine the ability of transforming growth factor (TGF) beta 1 to down-regulate immune responses in vivo. Preliminary experiments suggested that, at the doses used, systemic injection of soluble TGF beta 1 could not affect bacterial-induced spleen enlargement in mice. Therefore, we sought to utilize a physiochemical property of this molecule, namely its high pI, to determine possible association between the ligand and preformed liposomes possessing an opposite charge. TGF beta 1 was preferentially associated with negatively charged, but not with neutral, liposomes. These TGF beta 1 associated liposomes were able to deliver a suppressive signal to indicator cells in vitro. Intravenous injection of TGF beta 1, associated with liposomes possessing an opposite charge, into mice immunized with heat-killed Corynebacterium parvum significantly reduced the size of the spleen as well as the number of splenocytes. Systemically administered TGF beta 1 associated liposomes could also inhibit delayed type hypersensitivity reactions to Listeria monocytogenes. These data suggest that appropriately administered, TGF beta 1 can inhibit immune responses in vivo. | lld:pubmed |
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| pubmed-article:1747960 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1747960 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1747960 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1747960 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1747960 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1747960 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:1747960 | pubmed:author | pubmed-author:StrassmannGG | lld:pubmed |
| pubmed-article:1747960 | pubmed:author | pubmed-author:EidelmanOO | lld:pubmed |
| pubmed-article:1747960 | pubmed:author | pubmed-author:BertoliniD... | lld:pubmed |
| pubmed-article:1747960 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1747960 | pubmed:volume | 86 | lld:pubmed |
| pubmed-article:1747960 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1747960 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1747960 | pubmed:pagination | 532-6 | lld:pubmed |
| pubmed-article:1747960 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:1747960 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1747960 | pubmed:articleTitle | Inhibition of immune reactions in vivo by liposome associated transforming growth factor (TGF) type beta 1. | lld:pubmed |
| pubmed-article:1747960 | pubmed:affiliation | Maryland Research Laboratories, Otsuka America Pharmaceutical Co., Inc. Rockville 20850. | lld:pubmed |
| pubmed-article:1747960 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1747960 | lld:pubmed |
