|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1992-1-21
|
|
pubmed:abstractText |
Complement activation in 73 renal transplant biopsies was investigated by indirect immunoperoxidase staining using MoAbs reactive with complement-split products. Intense deposition of complement fragments C4d and C3d in peritubular capillaries, indicating activation of the classical pathway, could be detected in the majority of transplanted kidneys with cell-mediated rejections. Abundant deposition of complement-split products was observed in 22 early biopsies from patients with high 'immunological risk' (i.e. previous, rejected transplants and/or circulating antibodies against HLA-antigens). Despite negative results in the crossmatch before transplantation and paucity of immunoglobulins in transplant biopsies, antibodies directed against endothelial cell antigens should be considered as a possible cause of classical complement activation.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747954-14248725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747954-2507578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747954-2644563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747954-2689750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747954-2725646,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747954-2925226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747954-2973431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747954-3041799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747954-3279637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747954-3488995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747954-3537447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747954-3546915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747954-373180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747954-3919480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747954-4177387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747954-4550987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747954-5101107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747954-6222909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747954-6315852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747954-6387982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747954-6806664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747954-6950384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747954-7029812,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747954-7036451,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747954-7451988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747954-874103
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0009-9104
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
86
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
464-70
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:1747954-Antibodies, Monoclonal,
pubmed-meshheading:1747954-Biopsy,
pubmed-meshheading:1747954-Capillaries,
pubmed-meshheading:1747954-Complement Activation,
pubmed-meshheading:1747954-Complement C4,
pubmed-meshheading:1747954-Complement C4b,
pubmed-meshheading:1747954-Cyclosporine,
pubmed-meshheading:1747954-Glomerulonephritis,
pubmed-meshheading:1747954-Graft Rejection,
pubmed-meshheading:1747954-Humans,
pubmed-meshheading:1747954-Immunity, Cellular,
pubmed-meshheading:1747954-Immunoenzyme Techniques,
pubmed-meshheading:1747954-Immunoglobulin M,
pubmed-meshheading:1747954-Ischemia,
pubmed-meshheading:1747954-Kidney,
pubmed-meshheading:1747954-Kidney Transplantation,
pubmed-meshheading:1747954-Peptide Fragments,
pubmed-meshheading:1747954-Transplantation, Homologous
|
|
pubmed:year |
1991
|
|
pubmed:articleTitle |
Vascular deposition of complement-split products in kidney allografts with cell-mediated rejection.
|
|
pubmed:affiliation |
Medizinische Klinik Innenstadt, University of Munich, Germany.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
