|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0024264,
umls-concept:C0029001,
umls-concept:C0086418,
umls-concept:C0205369,
umls-concept:C0205370,
umls-concept:C0234402,
umls-concept:C0301625,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1992-1-21
|
|
pubmed:abstractText |
Characterization of in vitro lymphocyte responsiveness was performed on selected groups of onchocerciasis patients from Sudan and Sierra Leone. These patients manifested a very broad range of clinical signs and showed widely divergent parasite infection intensities. Lymphocyte proliferative responses to soluble Onchocerca volvulus antigen (sAg) were poor in infected persons; mitogen and PPD responses were maintained in the normal range in one group of patients from southwestern Sudan, but were profoundly depressed in a group from N.E. Sudan. Proliferative responses and interferon-gamma (INF-gamma) secretion were very significantly depressed in the presence of live microfilariae of O. volvulus or secretions/excretions (S/E) from microfilariae (mf) or from female, but not male, adult parasites. Lymphocyte responses were maintained near normal when exogenous IL-2 was added to these cultures. The results indicate that O. volvulus infection and its clinical consequences are not consistently associated with systemic deficits in immune responsiveness. However, suppression of lymphocyte reactivity by mf and S/E in vitro suggests that direct parasite intervention in host cell responses could be taking place in vivo, perhaps at the local microenvironment level; mediated by effects on cytokine production.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747951-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747951-15462735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747951-203061,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747951-2469719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747951-2567440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747951-2892371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747951-2937843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747951-3125261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747951-3257994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747951-3297560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747951-332621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747951-3446029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747951-3603620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747951-3826496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747951-4070918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747951-4082257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747951-5777735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747951-6118034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747951-6178026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747951-6444695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747951-64835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747951-6523561,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747951-6825449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747951-6861374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747951-6868339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1747951-705843
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0009-9104
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
86
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
433-9
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:1747951-Animals,
pubmed-meshheading:1747951-Antigens, Helminth,
pubmed-meshheading:1747951-Concanavalin A,
pubmed-meshheading:1747951-Female,
pubmed-meshheading:1747951-Humans,
pubmed-meshheading:1747951-Immunity, Cellular,
pubmed-meshheading:1747951-Interferon-gamma,
pubmed-meshheading:1747951-Interleukin-2,
pubmed-meshheading:1747951-Lymphocyte Activation,
pubmed-meshheading:1747951-Male,
pubmed-meshheading:1747951-Microfilaria,
pubmed-meshheading:1747951-Onchocerca,
pubmed-meshheading:1747951-Onchocerciasis,
pubmed-meshheading:1747951-Phytohemagglutinins,
pubmed-meshheading:1747951-Sex Factors
|
|
pubmed:year |
1991
|
|
pubmed:articleTitle |
Suppression of human lymphocyte responses to specific and non-specific stimuli in human onchocerciasis.
|
|
pubmed:affiliation |
Department of Microbiology and Public Health, Michigan State University, East Lansing.
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
|
