| pubmed-article:17478639 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17478639 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:17478639 | lifeskim:mentions | umls-concept:C0001792 | lld:lifeskim |
| pubmed-article:17478639 | lifeskim:mentions | umls-concept:C0039198 | lld:lifeskim |
| pubmed-article:17478639 | lifeskim:mentions | umls-concept:C0856825 | lld:lifeskim |
| pubmed-article:17478639 | lifeskim:mentions | umls-concept:C1416467 | lld:lifeskim |
| pubmed-article:17478639 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:17478639 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:17478639 | pubmed:dateCreated | 2007-8-22 | lld:pubmed |
| pubmed-article:17478639 | pubmed:abstractText | Selective depletion (SD) of host-reactive donor T cells from allogeneic stem-cell transplants (SCTs) using an anti-CD25 immunotoxin (IT) is a strategy to prevent acute graft-versus-host disease (aGvHD). There is concern that concurrent removal of regulatory T cells (T(regs)) with incomplete removal of alloactivated CD25(+) T cells could increase the risk of aGvHD. We therefore measured T(regs) in the blood of 16 patients receiving a T-cell-depleted allograft together with anti-CD25-IT-treated SD lymphocytes, in 13 of their HLA-identical donors, and in 10 SD products. T(regs) were characterized by intracellular staining for forkhead box protein 3 (FOXP3) and by quantitative reverse-transcription-polymerase chain reaction (qRT-PCR) for FOXP3 gene in CD4(+) cells. Patients received a median of 1.0 x 10(8)/kg SD T cells and a stem cell product containing a median of 0.25 x 10(4)/kg residual T cells. T(regs) reconstituted promptly after SCT and underwent further expansion. Of the CD4(+) T cells in SD products, 1.5% to 4.8% were CD25(-) T(regs). Acute GvHD (>or= grade II) was restricted to 5 patients whose donors had significantly (P = .019) fewer T(regs) compared with those without clinically significant aGvHD. These results suggest that rapid T(reg) reconstitution can occur following SD allografts, either from CD25(-) T(regs) escaping depletion, or from residual CD25(-) and CD25(+) T(regs) contained in the stem-cell product that expand after transplantation and may confer additional protection against GvHD. | lld:pubmed |
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| pubmed-article:17478639 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17478639 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17478639 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:17478639 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17478639 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:17478639 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:17478639 | pubmed:author | pubmed-author:BarrettA... | lld:pubmed |
| pubmed-article:17478639 | pubmed:author | pubmed-author:MielkeStephan... | lld:pubmed |
| pubmed-article:17478639 | pubmed:author | pubmed-author:ReadElizabeth... | lld:pubmed |
| pubmed-article:17478639 | pubmed:author | pubmed-author:GhetieVictorV | lld:pubmed |
| pubmed-article:17478639 | pubmed:author | pubmed-author:VitettaEllen... | lld:pubmed |
| pubmed-article:17478639 | pubmed:author | pubmed-author:SchindlerJohn... | lld:pubmed |
| pubmed-article:17478639 | pubmed:author | pubmed-author:RezvaniKatayo... | lld:pubmed |
| pubmed-article:17478639 | pubmed:author | pubmed-author:KurlanderRoge... | lld:pubmed |
| pubmed-article:17478639 | pubmed:author | pubmed-author:SavaniBipin... | lld:pubmed |
| pubmed-article:17478639 | pubmed:author | pubmed-author:SolomonScott... | lld:pubmed |
| pubmed-article:17478639 | pubmed:author | pubmed-author:YongAgnes S... | lld:pubmed |
| pubmed-article:17478639 | pubmed:author | pubmed-author:NunesRaquelR | lld:pubmed |
| pubmed-article:17478639 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17478639 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:17478639 | pubmed:volume | 110 | lld:pubmed |
| pubmed-article:17478639 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17478639 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17478639 | pubmed:pagination | 1689-97 | lld:pubmed |
| pubmed-article:17478639 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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