Linked Life Data

17478639

Source:http://linkedlifedata.com/resource/pubmed/id/17478639

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2007-8-22
pubmed:abstractText
Selective depletion (SD) of host-reactive donor T cells from allogeneic stem-cell transplants (SCTs) using an anti-CD25 immunotoxin (IT) is a strategy to prevent acute graft-versus-host disease (aGvHD). There is concern that concurrent removal of regulatory T cells (T(regs)) with incomplete removal of alloactivated CD25(+) T cells could increase the risk of aGvHD. We therefore measured T(regs) in the blood of 16 patients receiving a T-cell-depleted allograft together with anti-CD25-IT-treated SD lymphocytes, in 13 of their HLA-identical donors, and in 10 SD products. T(regs) were characterized by intracellular staining for forkhead box protein 3 (FOXP3) and by quantitative reverse-transcription-polymerase chain reaction (qRT-PCR) for FOXP3 gene in CD4(+) cells. Patients received a median of 1.0 x 10(8)/kg SD T cells and a stem cell product containing a median of 0.25 x 10(4)/kg residual T cells. T(regs) reconstituted promptly after SCT and underwent further expansion. Of the CD4(+) T cells in SD products, 1.5% to 4.8% were CD25(-) T(regs). Acute GvHD (>or= grade II) was restricted to 5 patients whose donors had significantly (P = .019) fewer T(regs) compared with those without clinically significant aGvHD. These results suggest that rapid T(reg) reconstitution can occur following SD allografts, either from CD25(-) T(regs) escaping depletion, or from residual CD25(-) and CD25(+) T(regs) contained in the stem-cell product that expand after transplantation and may confer additional protection against GvHD.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-10520038, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-10886218, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-10933186, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-11046015, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-11929798, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-11964269, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-11986199, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-12036894, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-12091325, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-12126823, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-12163567, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-12394170, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-12473206, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-12522256, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-12531922, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-12612578, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-12612581, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-12763937, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-12925844, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-12937844, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-14525783, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-14597756, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-14597769, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-15172973, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-15282533, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-15284108, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-15817673, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-15939793, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-15972448, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-16040390, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-16227988, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-16278306, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-16327814, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-16444279, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-16627754, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-16709816, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-16741253, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-16903903, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-16931626, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-1994250, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-2142343, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-7515723, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-7636184, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-8733700, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-8908518, http://linkedlifedata.com/resource/pubmed/commentcorrection/17478639-9520302
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0006-4971
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
110
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1689-97
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
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