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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
1992-1-22
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pubmed:abstractText |
Chronic administration of lipopolysaccharide (LPS) to mice markedly reduced activation of the neuroendocrine stress axis elicited by an acute challenge dose of LPS. LPS-induced elevation in norepinephrine turnover in the hypothalamus showed complete tolerance whereas elevation of plasma corticosterone showed only partial tolerance. Challenge-induced increased turnover of dopamine in hypothalamus persisted in LPS-tolerant animals. Neuroendocrine activation persisted following acute challenge with interleukin-1 and tumor necrosis factor following chronic LPS exposure.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0006-8993
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
557
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
327-30
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:1747764-Animals,
pubmed-meshheading:1747764-Biogenic Monoamines,
pubmed-meshheading:1747764-Corticosterone,
pubmed-meshheading:1747764-Cytokines,
pubmed-meshheading:1747764-Dopamine,
pubmed-meshheading:1747764-Drug Tolerance,
pubmed-meshheading:1747764-Endotoxins,
pubmed-meshheading:1747764-Hypothalamus,
pubmed-meshheading:1747764-Interleukin-1,
pubmed-meshheading:1747764-Lipopolysaccharides,
pubmed-meshheading:1747764-Macrophages,
pubmed-meshheading:1747764-Male,
pubmed-meshheading:1747764-Mice,
pubmed-meshheading:1747764-Mice, Inbred C57BL,
pubmed-meshheading:1747764-Neurosecretory Systems,
pubmed-meshheading:1747764-Norepinephrine,
pubmed-meshheading:1747764-Stress, Physiological,
pubmed-meshheading:1747764-Tumor Necrosis Factor-alpha
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pubmed:year |
1991
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pubmed:articleTitle |
Cytokine-induced activation of the neuroendocrine stress axis persists in endotoxin-tolerant mice.
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pubmed:affiliation |
Section of Clinical Pharmacology, National Institute of Mental Health, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892.
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pubmed:publicationType |
Journal Article
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