Source:http://linkedlifedata.com/resource/pubmed/id/17475367
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2007-7-9
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| pubmed:abstractText |
The pathway for selective serotonergic toxicity of 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") is poorly understood, but has been linked to hyperthermia and disturbed energy metabolism. We investigated the dose-dependency and time-course of MDMA-induced perturbations of cerebral glucose metabolism in freely moving rats using rapid sampling microdialysis (every minute) coupled to flow-injection analysis (FIA) with biosensors for glucose and lactate. Blood samples for analysis of glucose and lactate were taken at 30-45 min intervals before and after drug dosing and body temperature was monitored by telemetry. A single dose of MDMA (2-10-20 mg/kg i.v.) evoked a transient increase of interstitial glucose concentrations in striatum (139-223%) with rapid onset and of less than 2h duration, a concomitant but more prolonged lactate increase (>187%) at the highest MDMA dose and no significant depletions of striatal serotonin. Blood glucose and lactate levels were also transiently elevated (163 and 135%) at the highest MDMA doses. The blood glucose rises were significantly related to brain glucose and brain lactate changes. The metabolic perturbations in striatum and the hyperthermic response (+1.1 degrees C) following systemic MDMA treatment were entirely blocked in p-chlorophenylalanine pre-treated rats, indicating that these effects are mediated by endogenous serotonin.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Fenclonine,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Lactic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/N-Methyl-3,4-methylenedioxyamphetami...,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Antagonists
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
0197-0186
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
51
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
8-15
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| pubmed:meshHeading |
pubmed-meshheading:17475367-Animals,
pubmed-meshheading:17475367-Body Temperature,
pubmed-meshheading:17475367-Corpus Striatum,
pubmed-meshheading:17475367-Dose-Response Relationship, Drug,
pubmed-meshheading:17475367-Energy Metabolism,
pubmed-meshheading:17475367-Extracellular Fluid,
pubmed-meshheading:17475367-Fenclonine,
pubmed-meshheading:17475367-Fever,
pubmed-meshheading:17475367-Glucose,
pubmed-meshheading:17475367-Lactic Acid,
pubmed-meshheading:17475367-Male,
pubmed-meshheading:17475367-Microdialysis,
pubmed-meshheading:17475367-N-Methyl-3,4-methylenedioxyamphetamine,
pubmed-meshheading:17475367-Rats,
pubmed-meshheading:17475367-Rats, Sprague-Dawley,
pubmed-meshheading:17475367-Serotonin,
pubmed-meshheading:17475367-Serotonin Agents,
pubmed-meshheading:17475367-Serotonin Antagonists,
pubmed-meshheading:17475367-Time Factors,
pubmed-meshheading:17475367-Wakefulness
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| pubmed:year |
2007
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| pubmed:articleTitle |
Serotonin mediates rapid changes of striatal glucose and lactate metabolism after systemic 3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") administration in awake rats.
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| pubmed:affiliation |
Anatomy & Neurobiology, Institute of Medical Biology, University of Southern Denmark, Winsløwparken 21, DK-5000 Odense C, Denmark. jbgramsbergen@health.sdu.dk
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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