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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2007-5-3
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pubmed:abstractText |
While the apolipoprotein E (APOE) epsilon allele is a well-established risk factor for late-onset Alzheimer's disease (AD), initial genome scans using microsatellite markers in late-onset AD failed to identify this locus on chromosome 19. Recently developed methods for the simultaneous assessment of hundreds of thousands of single nucleotide polymorphisms (SNPs) promise to help more precisely identify loci that contribute to the risk of AD and other common multigenic conditions. We sought here to demonstrate that more precise identification of loci that are associated with complex, multi-genic genetic disorders can be achieved using ultra-high-density whole-genome associations by demonstrating their ability to identify the APOE locus as a major susceptibility gene for late-onset AD, despite the absence of SNPs within the APOE locus itself, as well as to refine odds ratios (ORs) based on gold-standard phenotyping of the study population.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1555-2101
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pubmed:author |
pubmed-author:BeachThomas GTG,
pubmed-author:BrydenLeslieL,
pubmed-author:CoonKeith DKD,
pubmed-author:CraigDavid WDW,
pubmed-author:HalperinRebecca FRF,
pubmed-author:HardyJohnJ,
pubmed-author:HewardChristopher BCB,
pubmed-author:KaleemMonaM,
pubmed-author:LeungDorisD,
pubmed-author:LinceDiane HuDH,
pubmed-author:MarloweLaurenL,
pubmed-author:MyersAmanda JAJ,
pubmed-author:PapassotiropoulosAndreasA,
pubmed-author:PearsonJohn VJV,
pubmed-author:RavidRivkaR,
pubmed-author:ReimanEric MEM,
pubmed-author:RogersJosephJ,
pubmed-author:StephanDietrich ADA,
pubmed-author:WalkerDouglas GDG,
pubmed-author:WebsterJennifer AJA,
pubmed-author:ZismannVictoria LVL
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pubmed:issnType |
Electronic
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
613-8
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:17474819-Age of Onset,
pubmed-meshheading:17474819-Aged,
pubmed-meshheading:17474819-Aged, 80 and over,
pubmed-meshheading:17474819-Alzheimer Disease,
pubmed-meshheading:17474819-Apolipoproteins E,
pubmed-meshheading:17474819-Brain,
pubmed-meshheading:17474819-Case-Control Studies,
pubmed-meshheading:17474819-Chromosome Mapping,
pubmed-meshheading:17474819-Chromosomes, Human, Pair 19,
pubmed-meshheading:17474819-Female,
pubmed-meshheading:17474819-Genetic Predisposition to Disease,
pubmed-meshheading:17474819-Humans,
pubmed-meshheading:17474819-Male,
pubmed-meshheading:17474819-Odds Ratio,
pubmed-meshheading:17474819-Polymorphism, Single Nucleotide,
pubmed-meshheading:17474819-Risk Factors
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pubmed:year |
2007
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pubmed:articleTitle |
A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease.
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pubmed:affiliation |
Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Ariz. 85004, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural,
Research Support, N.I.H., Intramural
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