Source:http://linkedlifedata.com/resource/pubmed/id/17473392
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2007-5-2
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pubmed:abstractText |
Major depressive disorder is often associated with elevated glucocorticoid levels, which in turn suppress cell proliferation and neurogenesis in the hippocampus. Increasing evidence supports that antidepressants induce hippocampal neurogenesis and this induces speculation that decrease in hippocampal neurogenesis has causal relationship with depression. There is, however, a lack of information about neurogenic effects of antidepressants on the subventricular zone, which is another CNS region with continuous neurogenesis throughout adulthood. In the present study, we investigated whether corticosterone and the SSRI paroxetine, have effects on SVZ cell proliferation.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0922-6028
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
17-23
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pubmed:meshHeading |
pubmed-meshheading:17473392-Adrenal Cortex Hormones,
pubmed-meshheading:17473392-Animals,
pubmed-meshheading:17473392-Bromodeoxyuridine,
pubmed-meshheading:17473392-Cell Count,
pubmed-meshheading:17473392-Cell Proliferation,
pubmed-meshheading:17473392-Cerebral Ventricles,
pubmed-meshheading:17473392-Drug Interactions,
pubmed-meshheading:17473392-Male,
pubmed-meshheading:17473392-Paroxetine,
pubmed-meshheading:17473392-Rats,
pubmed-meshheading:17473392-Rats, Sprague-Dawley,
pubmed-meshheading:17473392-Serotonin Uptake Inhibitors,
pubmed-meshheading:17473392-Statistics, Nonparametric,
pubmed-meshheading:17473392-Time Factors
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pubmed:year |
2007
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pubmed:articleTitle |
Corticosteroid decreases subventricular zone cell proliferation, which could be reversed by paroxetine.
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pubmed:affiliation |
Department of Psychiatry, The University of Hong Kong, Hong Kong, China.
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pubmed:publicationType |
Journal Article
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