|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0127400,
umls-concept:C0174680,
umls-concept:C0185117,
umls-concept:C0279023,
umls-concept:C0301625,
umls-concept:C0334227,
umls-concept:C0346647,
umls-concept:C0441655,
umls-concept:C0521447,
umls-concept:C2911684
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|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2007-5-2
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|
pubmed:abstractText |
Pancreatic cancer is a highly aggressive disease that remains refractory to various chemotherapeutic agents. Because the proto-oncogene c-myc can modulate apoptosis in response to cytotoxic insults and is commonly overexpressed in pancreatic cancer, we investigated the value of c-myc as a potential modulator of cellular response to various chemotherapeutic agents.
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pubmed:grant |
|
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
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pubmed:issn |
1078-0432
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|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
13
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
2811-21
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:17473215-Animals,
pubmed-meshheading:17473215-Antineoplastic Agents,
pubmed-meshheading:17473215-Apoptosis,
pubmed-meshheading:17473215-Cell Line, Tumor,
pubmed-meshheading:17473215-Cell Survival,
pubmed-meshheading:17473215-Cisplatin,
pubmed-meshheading:17473215-Cyclin D1,
pubmed-meshheading:17473215-DNA Fragmentation,
pubmed-meshheading:17473215-Drug Resistance, Neoplasm,
pubmed-meshheading:17473215-Humans,
pubmed-meshheading:17473215-Mice,
pubmed-meshheading:17473215-NF-kappa B,
pubmed-meshheading:17473215-Pancreatic Neoplasms,
pubmed-meshheading:17473215-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:17473215-RNA, Small Interfering
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|
pubmed:year |
2007
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|
pubmed:articleTitle |
c-Myc-induced chemosensitization is mediated by suppression of cyclin D1 expression and nuclear factor-kappa B activity in pancreatic cancer cells.
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|
pubmed:affiliation |
Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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