rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
9
|
pubmed:dateCreated |
2007-5-2
|
pubmed:abstractText |
This phase I study evaluated the effect of folate supplementation on the toxicity, tolerability, and pharmacokinetics of pemetrexed in patients with locally advanced or metastatic cancer. It also examined two different types of vitamin supplementation and whether the extent of prior myelosuppressive therapy affected pemetrexed tolerability. Patients and Methods: Patients received a 10-min infusion of 600 to 14,00 mg/m(2) pemetrexed every 3 weeks. Patients were stratified into cohorts by pretreatment status [lightly pretreated (LPT) or heavily pretreated (HPT)] and were supplemented with intermittent high-dose folic acid (HDFA) or with continuous daily multivitamins (MVI) containing nutritional doses of folic acid. Pemetrexed plasma pharmacokinetics were evaluated for cycle 1.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
1078-0432
|
pubmed:author |
pubmed-author:BeeramMuralidharM,
pubmed-author:ClarkRomneeR,
pubmed-author:ForeroLeonardoL,
pubmed-author:ForouzeshBahramB,
pubmed-author:Hammond-ThelinLisa ALA,
pubmed-author:LatzJane EJE,
pubmed-author:MonroePamelaP,
pubmed-author:PatnaikAmitaA,
pubmed-author:RowinskyEric KEK,
pubmed-author:SchneckKaren BKB,
pubmed-author:TakimotoChris HCH,
pubmed-author:TolcherAnthony WAW,
pubmed-author:WoodLeslieL,
pubmed-author:de BonoJohannJ
|
pubmed:issnType |
Print
|
pubmed:day |
1
|
pubmed:volume |
13
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
2675-83
|
pubmed:meshHeading |
pubmed-meshheading:17473199-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:17473199-Dietary Supplements,
pubmed-meshheading:17473199-Female,
pubmed-meshheading:17473199-Folic Acid,
pubmed-meshheading:17473199-Glutamates,
pubmed-meshheading:17473199-Guanine,
pubmed-meshheading:17473199-Humans,
pubmed-meshheading:17473199-Infusions, Parenteral,
pubmed-meshheading:17473199-Male,
pubmed-meshheading:17473199-Neoplasm Metastasis,
pubmed-meshheading:17473199-Neoplasms,
pubmed-meshheading:17473199-Vitamin B Complex
|
pubmed:year |
2007
|
pubmed:articleTitle |
Phase I and pharmacokinetic study of pemetrexed with high-dose folic acid supplementation or multivitamin supplementation in patients with locally advanced or metastatic cancer.
|
pubmed:affiliation |
Institute for Drug Development at the Cancer Therapy and Research Center and University of Texas Health Science Center, San Antonio, Texas 78245-3217, USA. ctakimot@idd.org
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Clinical Trial, Phase I
|