rdf:type |
|
lifeskim:mentions |
umls-concept:C0007587,
umls-concept:C0008838,
umls-concept:C0017262,
umls-concept:C0086418,
umls-concept:C0166417,
umls-concept:C0185117,
umls-concept:C0205263,
umls-concept:C0205396,
umls-concept:C0205419,
umls-concept:C0242379,
umls-concept:C0242606,
umls-concept:C2911684
|
pubmed:issue |
9
|
pubmed:dateCreated |
2007-5-2
|
pubmed:abstractText |
The activation of peroxisome proliferator-activated receptor gamma (PPAR gamma) has been implicated in the inhibition of tumor progression in lung cancers through the induction of differentiation and apoptosis. Recently, we identified a novel splice variant of human PPAR gamma1 (hPPAR gamma1) that exhibits dominant-negative activity in human tumor-derived cell lines. This study aimed to examine the expression and pathophysiologic roles of a truncated splice variant of hPPAR gamma1 (hPPAR gamma1(tr)) in primary human lung cancer tissues.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
1078-0432
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
1
|
pubmed:volume |
13
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
2577-83
|
pubmed:meshHeading |
pubmed-meshheading:17473186-Alternative Splicing,
pubmed-meshheading:17473186-Antineoplastic Agents,
pubmed-meshheading:17473186-Apoptosis,
pubmed-meshheading:17473186-Carcinoma, Squamous Cell,
pubmed-meshheading:17473186-Cell Death,
pubmed-meshheading:17473186-Cell Nucleus,
pubmed-meshheading:17473186-Cisplatin,
pubmed-meshheading:17473186-Drug Resistance, Neoplasm,
pubmed-meshheading:17473186-Humans,
pubmed-meshheading:17473186-Lung Neoplasms,
pubmed-meshheading:17473186-Oxidative Stress,
pubmed-meshheading:17473186-PPAR gamma,
pubmed-meshheading:17473186-RNA, Small Interfering,
pubmed-meshheading:17473186-Tumor Cells, Cultured
|
pubmed:year |
2007
|
pubmed:articleTitle |
Expression of a peroxisome proliferator-activated receptor gamma 1 splice variant that was identified in human lung cancers suppresses cell death induced by cisplatin and oxidative stress.
|
pubmed:affiliation |
Department of Pharmacology, Gyeongsang Institute of Health Science, College of Medicine, Gyeongsang National University, Jinju, Korea.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|