Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2007-8-10
pubmed:abstractText
Sjögren's syndrome is an autoimmune disease in which immune cells chronically attack the lachrymal and salivary glands. The Id3 knockout mouse is a newly established animal model for primary Sjögren's syndrome. To address the role of B cells in Sjögren's syndrome and autoimmune disease, we studied the effect of CD20 monoclonal antibody treatment on the disease in Id3 knockout mice. Antibody treatment at 2-month intervals led to efficient and sustained B-cell depletion in Id3 knockout mice. A significant improvement of histopathology was observed accompanied by the recovery of saliva secretory function after CD20 antibody treatment. We further show that serum immunoglobulin G3, which is abnormally high in untreated Id3 knockout mice, was reduced after CD20 antibody treatment. This study establishes a new animal model for immunotherapy of Sjögren's symptoms and suggests a possible link between immunoglobulin G3 and disease pathology in Id3 knockout mice.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17472721-10446879, http://linkedlifedata.com/resource/pubmed/commentcorrection/17472721-10454544, http://linkedlifedata.com/resource/pubmed/commentcorrection/17472721-10503656, http://linkedlifedata.com/resource/pubmed/commentcorrection/17472721-10933599, http://linkedlifedata.com/resource/pubmed/commentcorrection/17472721-11257159, http://linkedlifedata.com/resource/pubmed/commentcorrection/17472721-12006334, http://linkedlifedata.com/resource/pubmed/commentcorrection/17472721-12108757, http://linkedlifedata.com/resource/pubmed/commentcorrection/17472721-12794814, http://linkedlifedata.com/resource/pubmed/commentcorrection/17472721-15210744, http://linkedlifedata.com/resource/pubmed/commentcorrection/17472721-15485632, http://linkedlifedata.com/resource/pubmed/commentcorrection/17472721-15778404, http://linkedlifedata.com/resource/pubmed/commentcorrection/17472721-15888503, http://linkedlifedata.com/resource/pubmed/commentcorrection/17472721-16039337, http://linkedlifedata.com/resource/pubmed/commentcorrection/17472721-16142737, http://linkedlifedata.com/resource/pubmed/commentcorrection/17472721-16239389, http://linkedlifedata.com/resource/pubmed/commentcorrection/17472721-16283417, http://linkedlifedata.com/resource/pubmed/commentcorrection/17472721-16287762, http://linkedlifedata.com/resource/pubmed/commentcorrection/17472721-16882600, http://linkedlifedata.com/resource/pubmed/commentcorrection/17472721-16935916, http://linkedlifedata.com/resource/pubmed/commentcorrection/17472721-7524522, http://linkedlifedata.com/resource/pubmed/commentcorrection/17472721-7542548, http://linkedlifedata.com/resource/pubmed/commentcorrection/17472721-8256202
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0019-2805
pubmed:author
pubmed:issnType
Print
pubmed:volume
122
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
73-9
pubmed:dateRevised
2011-6-7
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
B-lymphocyte depletion ameliorates Sjögren's syndrome in Id3 knockout mice.
pubmed:affiliation
Department of Immunology, Duke University Medical Center, Durham, NC, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Evaluation Studies, Research Support, N.I.H., Extramural