Linked Life Data

1747158

Source:http://linkedlifedata.com/resource/pubmed/id/1747158

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1991-9-26
pubmed:abstractText
The effects of neuropeptide Y (NPY; 1-36) and NPY fragment (16-36) on nicotinic currents (IACh) and voltage-dependent calcium currents (ICa) were studied in bovine chromaffin cells using the whole-cell patch-clamp technique. The peak amplitude of inward nicotinic currents was markedly depressed by both NPY (1-36) and NPY (16-36). In contrast, ICa was unaffected by either NPY (1-36) or NPY (16-36). Both pertussis toxin pretreatment and including GDP [beta-S] in the patch pipette solution completely abolished the inhibitory effect of NPY on IACh. It is concluded that inhibition of IACh probably represents the mechanism by which NPY decreases catecholamine release from adrenal medulla. This effect appears to be mediated by a G-protein-coupled Y2 receptor.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0031-6768
pubmed:author
pubmed:issnType
Print
pubmed:volume
418
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
346-52
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Neuropeptide Y inhibits nicotinic cholinergic currents but not voltage-dependent calcium currents in bovine chromaffin cells.
pubmed:affiliation
University of Freiburg, Department of Pharmacology, Federal Republic of Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't