Linked Life Data

17471506

Source:http://linkedlifedata.com/resource/pubmed/id/17471506

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2007-11-20
pubmed:abstractText
A mononuclear 1:1 copper complex of curcumin had been found to be superior to curcumin in its anti-oxidant properties. This paper describes the radio-protective effects of the complex in splenic lymphocytes from swiss mice. The complex was found to be very effective in protecting the cells against radiation-induced suppression of glutathione peroxidase, catalase and superoxide dismutase (SOD) activities. Both curcumin and the complex protected radiation-induced protein carbonylation and lipid peroxidation in lymphocytes with the complex showing better protection than curcumin. It also showed better overall protection by decreasing the radiation-induced apoptosis. The kinetics of activation of PKCdelta and NFkappaB after irradiation in presence or absence of these compounds was looked at to identify the molecular mechanism involved. The modulation of irradiation-induced activation of PKCdelta and NFkappaB by curcumin and the complex was found different at later time periods although the initial response was similar. The early responses could be mere stress responses and the activation of crucial signaling factors at later time periods may be the determinants of the fate of the cell. In this study this delayed effect was observed in case of complex but not in case of curcumin. The delayed effect of the complex along with the fact that it is a better free radical scavenger must be the reason for its better efficacy. The complex was also found to be less cytotoxic then curcumin at similar concentration.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0730-2312
pubmed:author
pubmed:copyrightInfo
(c) 2007 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
102
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1214-24
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:17471506-Animals, pubmed-meshheading:17471506-Apoptosis, pubmed-meshheading:17471506-Catalase, pubmed-meshheading:17471506-Copper, pubmed-meshheading:17471506-Curcumin, pubmed-meshheading:17471506-Enzyme Activation, pubmed-meshheading:17471506-Gamma Rays, pubmed-meshheading:17471506-Glutathione Peroxidase, pubmed-meshheading:17471506-Hydrogen-Ion Concentration, pubmed-meshheading:17471506-Kinetics, pubmed-meshheading:17471506-Lipid Peroxidation, pubmed-meshheading:17471506-Lymphocytes, pubmed-meshheading:17471506-Male, pubmed-meshheading:17471506-Mice, pubmed-meshheading:17471506-Mice, Inbred Strains, pubmed-meshheading:17471506-Molecular Structure, pubmed-meshheading:17471506-NF-kappa B, pubmed-meshheading:17471506-Protein Carbonylation, pubmed-meshheading:17471506-Protein Kinase C-delta, pubmed-meshheading:17471506-Radiation-Protective Agents, pubmed-meshheading:17471506-Spleen, pubmed-meshheading:17471506-Superoxide Dismutase
pubmed:year
2007
pubmed:articleTitle
Delayed activation of PKCdelta and NFkappaB and higher radioprotection in splenic lymphocytes by copper (II)-Curcumin (1:1) complex as compared to curcumin.
pubmed:affiliation
Radiation & Photochemistry Division, Bhabha Atomic Research Centre, Mumbai 400085, India.
pubmed:publicationType
Journal Article, Comparative Study