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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2007-5-1
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|
pubmed:abstractText |
Imatinib mesylate treatment causes remissions in a majority of patients with chronic myeloid leukemia (CML), but relapses are an increasing problem. We hypothesized that imatinib-resistant leukemic cells emerge from CML stem cells that acquire BCR-ABL gene mutations even before exposure to BCR-ABL-targeted agents such as imatinib.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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|
pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
May
|
|
pubmed:issn |
1460-2105
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pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:day |
2
|
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pubmed:volume |
99
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
680-93
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:17470736-Colony-Forming Units Assay,
pubmed-meshheading:17470736-DNA Mutational Analysis,
pubmed-meshheading:17470736-DNA Primers,
pubmed-meshheading:17470736-Genes, abl,
pubmed-meshheading:17470736-Genomic Instability,
pubmed-meshheading:17470736-Humans,
pubmed-meshheading:17470736-Immunomagnetic Separation,
pubmed-meshheading:17470736-In Situ Hybridization, Fluorescence,
pubmed-meshheading:17470736-Leukemia, Myelogenous, Chronic, BCR-ABL Positive,
pubmed-meshheading:17470736-Leukocyte Count,
pubmed-meshheading:17470736-Mutation,
pubmed-meshheading:17470736-Piperazines,
pubmed-meshheading:17470736-Protein Kinase Inhibitors,
pubmed-meshheading:17470736-Pyrimidines,
pubmed-meshheading:17470736-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17470736-Stem Cells,
pubmed-meshheading:17470736-Tumor Cells, Cultured
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pubmed:year |
2007
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pubmed:articleTitle |
Instability of BCR-ABL gene in primary and cultured chronic myeloid leukemia stem cells.
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pubmed:affiliation |
Terry Fox Laboratory, British Columbia Cancer Agency, 675 West 10th Ave, Vancouver, BC, V5Z 1L3, Canada. xjiang@bccrc.ca
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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