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rdf:type |
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lifeskim:mentions |
umls-concept:C0004083,
umls-concept:C0006675,
umls-concept:C0006736,
umls-concept:C0022646,
umls-concept:C0034897,
umls-concept:C0221102,
umls-concept:C0376259,
umls-concept:C0598850,
umls-concept:C0678951,
umls-concept:C1524119,
umls-concept:C2705716
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pubmed:issue |
4
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|
pubmed:dateCreated |
2007-5-1
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pubmed:abstractText |
Urinary citrate is a potent inhibitor of renal stone formation. Its excretion is regulated by Na(+)/dicarboxylate cotransporter-1 (NaDC-1), which is expressed on the apical membrane of renal proximal tubules. Many patients with calcium urolithiasis exhibit hypocitraturia, however, the mechanisms are not perfectly understood. We examined whether or not the I550V polymorphism in human NaDC-1 gene (hNaDC-1) influenced urinary citrate excretion.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0919-8172
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
344-9
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pubmed:meshHeading |
pubmed-meshheading:17470169-Case-Control Studies,
pubmed-meshheading:17470169-Citric Acid,
pubmed-meshheading:17470169-Dicarboxylic Acid Transporters,
pubmed-meshheading:17470169-Exons,
pubmed-meshheading:17470169-Female,
pubmed-meshheading:17470169-Genotype,
pubmed-meshheading:17470169-Humans,
pubmed-meshheading:17470169-Kidney Calculi,
pubmed-meshheading:17470169-Male,
pubmed-meshheading:17470169-Middle Aged,
pubmed-meshheading:17470169-Organic Anion Transporters, Sodium-Dependent,
pubmed-meshheading:17470169-Polymerase Chain Reaction,
pubmed-meshheading:17470169-Polymorphism, Single Nucleotide,
pubmed-meshheading:17470169-Recurrence,
pubmed-meshheading:17470169-Symporters
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pubmed:year |
2007
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pubmed:articleTitle |
Associations between renal sodium-citrate cotransporter (hNaDC-1) gene polymorphism and urinary citrate excretion in recurrent renal calcium stone formers and normal controls.
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pubmed:affiliation |
Department of Urology, University of Tokyo, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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