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pubmed-article:17469184pubmed:abstractTextThe principal effect of transforming growth factor beta1 (TGFbeta1) on mesenchymal cells is its stimulation of extracellular matrix synthesis. Previous reports indicated the significance of the autocrine TGFbeta loop in the pathogenesis of scleroderma. The aim of this study was to examine c-Ski and SnoN, principal molecules in the negative regulation of TGFbeta signaling, to further understand the autocrine TGFbeta loop in scleroderma.lld:pubmed
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pubmed-article:17469184pubmed:articleTitleInvolvement of the constitutive complex formation of c-Ski/SnoN with Smads in the impaired negative feedback regulation of transforming growth factor beta signaling in scleroderma fibroblasts.lld:pubmed
pubmed-article:17469184pubmed:affiliationUniversity of Tokyo, Tokyo, Japan.lld:pubmed
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