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rdf:type |
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lifeskim:mentions |
umls-concept:C0011644,
umls-concept:C0015744,
umls-concept:C0016030,
umls-concept:C0037083,
umls-concept:C0040690,
umls-concept:C0205160,
umls-concept:C0221099,
umls-concept:C0439855,
umls-concept:C0851285,
umls-concept:C1314939,
umls-concept:C1335828,
umls-concept:C1522492,
umls-concept:C1710082,
umls-concept:C2911691
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pubmed:issue |
5
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pubmed:dateCreated |
2007-5-14
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pubmed:abstractText |
The principal effect of transforming growth factor beta1 (TGFbeta1) on mesenchymal cells is its stimulation of extracellular matrix synthesis. Previous reports indicated the significance of the autocrine TGFbeta loop in the pathogenesis of scleroderma. The aim of this study was to examine c-Ski and SnoN, principal molecules in the negative regulation of TGFbeta signaling, to further understand the autocrine TGFbeta loop in scleroderma.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Collagen Type I,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/E1A-Associated p300 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/EP300 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SKI protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/SKIL protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/SMAD3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Smad3 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta1
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1694-705
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17469184-Adult,
pubmed-meshheading:17469184-Case-Control Studies,
pubmed-meshheading:17469184-Cells, Cultured,
pubmed-meshheading:17469184-Collagen Type I,
pubmed-meshheading:17469184-DNA-Binding Proteins,
pubmed-meshheading:17469184-E1A-Associated p300 Protein,
pubmed-meshheading:17469184-Feedback, Physiological,
pubmed-meshheading:17469184-Female,
pubmed-meshheading:17469184-Fibroblasts,
pubmed-meshheading:17469184-Gene Expression Regulation,
pubmed-meshheading:17469184-Humans,
pubmed-meshheading:17469184-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:17469184-Male,
pubmed-meshheading:17469184-Middle Aged,
pubmed-meshheading:17469184-Proto-Oncogene Proteins,
pubmed-meshheading:17469184-Scleroderma, Systemic,
pubmed-meshheading:17469184-Signal Transduction,
pubmed-meshheading:17469184-Smad3 Protein,
pubmed-meshheading:17469184-Transforming Growth Factor beta1
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pubmed:year |
2007
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pubmed:articleTitle |
Involvement of the constitutive complex formation of c-Ski/SnoN with Smads in the impaired negative feedback regulation of transforming growth factor beta signaling in scleroderma fibroblasts.
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pubmed:affiliation |
University of Tokyo, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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