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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2008-2-22
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pubmed:abstractText |
Protease nexin-1 (PN-1) belongs to the serpin family of serine protease inhibitors. It is the phylogenetically closest relative of plasminogen activator inhibitor-1 (PAI-1). Whilst there are numerous studies of the occurrence and functions of PAI-1 in cancer, a possible tumour biological role of PN-1 has been almost totally neglected. We have now compared the level of PN-1 mRNA in 20 cases of oral squamous cell carcinomas and in matched samples of the corresponding normal oral tissues. We found that the average PN-1 mRNA level in tumours and normal tissues was significantly different, being increased up to 13 fold in tumour samples compared with the average level in normal tissues. The PN-1 mRNA level was significantly higher in tumours from patients with lymph node metastasis than in tumours from patients without. We could conclude that PN-1 is frequently overexpressed in oral squamous cell carcinomas and that its level may correlate with the occurrence of lymph node metastasis. We hypothesise that PN-1 may have a tumour biological function similar to that of PAI-1.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amyloid beta-Protein Precursor,
http://linkedlifedata.com/resource/pubmed/chemical/Protease Nexins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/SERPINE2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Serpin E2,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1368-8375
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
309-13
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17468036-Aged,
pubmed-meshheading:17468036-Aged, 80 and over,
pubmed-meshheading:17468036-Amyloid beta-Protein Precursor,
pubmed-meshheading:17468036-Carcinoma, Squamous Cell,
pubmed-meshheading:17468036-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:17468036-Female,
pubmed-meshheading:17468036-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:17468036-Humans,
pubmed-meshheading:17468036-Immunoblotting,
pubmed-meshheading:17468036-Lymphatic Metastasis,
pubmed-meshheading:17468036-Male,
pubmed-meshheading:17468036-Middle Aged,
pubmed-meshheading:17468036-Mouth Neoplasms,
pubmed-meshheading:17468036-Protease Nexins,
pubmed-meshheading:17468036-RNA, Messenger,
pubmed-meshheading:17468036-Receptors, Cell Surface,
pubmed-meshheading:17468036-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17468036-Serpin E2,
pubmed-meshheading:17468036-Tumor Markers, Biological
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pubmed:year |
2008
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pubmed:articleTitle |
Overexpression of protease nexin-1 mRNA and protein in oral squamous cell carcinomas.
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pubmed:affiliation |
Department of Molecular Biology, University of Aarhus, Gustav Wied's Vej 10C, 8000 Aarhus C, Denmark. shg@mb.au.dk <shg@mb.au.dk>
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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