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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2007-4-30
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pubmed:abstractText |
The proinflammatory marker C-reactive protein has been demonstrated to play a role in the development of atherosclerosis. Endothelin-1 and nitric oxide homeostasis is crucial for normal vasomotor function, limiting inflammatory activation and maintaining a nonthrombogenic endothelial surface. In addition to its vasoactive properties, endothelin-1 is also an inflammatory cytokine. We have previously demonstrated that C-reactive protein impairs endothelial cell nitric oxide production. Protein kinase C, an important signal transducer within the cell, is involved in several cellular responses to external stimuli. We therefore sought to determine whether endothelin-1 exposure modulates C-reactive protein's effects on nitric oxide production via protein kinase C.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alkaloids,
http://linkedlifedata.com/resource/pubmed/chemical/Benzophenanthridines,
http://linkedlifedata.com/resource/pubmed/chemical/C-Reactive Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Endothelin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Naphthalenes,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type III,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/bosentan,
http://linkedlifedata.com/resource/pubmed/chemical/calphostin C,
http://linkedlifedata.com/resource/pubmed/chemical/chelerythrine
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1097-685X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
133
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1137-46
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:17467420-Alkaloids,
pubmed-meshheading:17467420-Atherosclerosis,
pubmed-meshheading:17467420-Benzophenanthridines,
pubmed-meshheading:17467420-C-Reactive Protein,
pubmed-meshheading:17467420-Cells, Cultured,
pubmed-meshheading:17467420-Cytokines,
pubmed-meshheading:17467420-Endothelin-1,
pubmed-meshheading:17467420-Endothelium, Vascular,
pubmed-meshheading:17467420-Homeostasis,
pubmed-meshheading:17467420-Humans,
pubmed-meshheading:17467420-Naphthalenes,
pubmed-meshheading:17467420-Nitric Oxide,
pubmed-meshheading:17467420-Nitric Oxide Synthase Type III,
pubmed-meshheading:17467420-Protein Kinase C,
pubmed-meshheading:17467420-Saphenous Vein,
pubmed-meshheading:17467420-Sulfonamides
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pubmed:year |
2007
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pubmed:articleTitle |
Endothelin-1 accentuates the proatherosclerotic effects associated with C-reactive protein.
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pubmed:affiliation |
Division of Cardiac Surgery, University of Toronto, Toronto, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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