Linked Life Data

17467346

Source:http://linkedlifedata.com/resource/pubmed/id/17467346

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
2007-9-24
pubmed:abstractText
In the adult human, the kidney is the main organ for the production and release of erythropoietin (EPO). EPO is stimulating erythropoiesis by increasing the proliferation, differentiation and maturation of the erythroid precursors. In the last decades, enormous efforts were made in the purification, molecular encoding and description of the EPO gene. This led to an incredible increase in the understanding of the EPO-feedback-regulation loop at a molecular level, especially the oxygen-dependent EPO gene expression, a key function in the regulation loop. However, studies in humans at a systemic level are still very scanty. Therefore, it is the purpose of the present review to report on the main recent investigations on EPO production and release in humans under different environmental and experimental conditions, including: (i) studies on EPO circadian, monthly and even annual variations, (ii) studies in connection with short-, medium- and long-term exercise at sea-level which will be followed (iii) by studies performed at moderate and high altitude.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1569-9048
pubmed:author
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
158
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
287-97
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Erythropoietin regulations in humans under different environmental and experimental conditions.
pubmed:affiliation
Institut für Physiologie, Zentrum für Weltraummedizin Berlin, Charite Campus Benjamin Franklin, Arnimallee 22, 14195 Berlin, Germany. hanns-christian.gunga@charite.de
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't