Linked Life Data

17466507

Source:http://linkedlifedata.com/resource/pubmed/id/17466507

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2007-6-18
pubmed:abstractText
Wrapping DNA into a nucleosome influences factor binding to cognate sites, and thus the positions of nucleosomes in eukaryotic genomes contribute to gene regulation. Nucleosome positioning is influenced by DNA sequence, chromatin remodelers and non-histone chromatin factors, and genomic maps of nucleosomes are now being constructed. However, interpretation of these maps requires consideration of chromatin dynamics, as even some positioned nucleosomes appear subject to rapid unwinding and eviction. The dynamic properties of nucleosomes contribute to several processes, including gene regulation, mechanisms of transcription and the inheritance of chromatin states. Understanding the positions and dynamic behavior of nucleosomes promises to shed light on why transcription factors bind so many fewer sites than predicted, how histone variants may be targeted, and how chromatin states are delineated.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0955-0674
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
250-6
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Rules and regulation in the primary structure of chromatin.
pubmed:affiliation
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
pubmed:publicationType
Journal Article, Review