Source:http://linkedlifedata.com/resource/pubmed/id/17466308
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2008-2-25
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| pubmed:abstractText |
Atherosclerotic vascular disease is an inflammatory disease. Interferon-beta (IFN-beta) is an important immune modulator. However, the role of IFN-beta in atherosclerotic vascular disease is still not clear. The present study is designed to determine the effects of IFN-beta on atherosclerosis, abdominal aortic aneurysm (AAA) formation and proliferative vascular remodeling in apolipoprotein E (apoE) deficient mice. Six-month-old male apoE deficient mice fed a normal chow underwent ligation of the common left carotid artery, and were randomly assigned to receive either vehicle or angiotensin II (Ang II, 1.4 mg/kg daily) via a subcutaneously implanted osmotic infusion pump. The animals were further assigned to groups that were subjected to subcutaneous injection of vehicle or murine IFN-beta (10 MIU/kg, daily). Ang II increased atherosclerotic area in the non-ligated carotid artery and aortic arch, induced AAA, and exacerbated ligation-induced adventitial proliferation and neointimal hyperplasia characterized by smooth muscle cell (SMC) proliferation and macrophage infiltration in the ligated carotid artery. Co-treatment with IFN-beta, had no effects by itself, significantly attenuated Ang II-accelerated increase in the areas of neointima, adventitia, SMC and macrophage in the ligated carotid artery and suppressed Ang II-exacerbated atherosclerosis, but did not affect Ang II-induced AAA formation. These data indicate that IFN-beta can play a prominent anti-atherosclerosis, anti-inflammation, and anti-proliferation role of vasculoprotection.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins E,
http://linkedlifedata.com/resource/pubmed/chemical/Immunologic Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-beta,
http://linkedlifedata.com/resource/pubmed/chemical/Vasoconstrictor Agents
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| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
1879-1484
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
197
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
204-11
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| pubmed:meshHeading |
pubmed-meshheading:17466308-Angiotensin II,
pubmed-meshheading:17466308-Animals,
pubmed-meshheading:17466308-Aorta, Thoracic,
pubmed-meshheading:17466308-Aortic Aneurysm, Abdominal,
pubmed-meshheading:17466308-Apolipoproteins E,
pubmed-meshheading:17466308-Atherosclerosis,
pubmed-meshheading:17466308-Carotid Artery, Common,
pubmed-meshheading:17466308-Cell Division,
pubmed-meshheading:17466308-Drug Interactions,
pubmed-meshheading:17466308-Foam Cells,
pubmed-meshheading:17466308-Immunologic Factors,
pubmed-meshheading:17466308-Interferon-beta,
pubmed-meshheading:17466308-Ligation,
pubmed-meshheading:17466308-Male,
pubmed-meshheading:17466308-Mice,
pubmed-meshheading:17466308-Mice, Mutant Strains,
pubmed-meshheading:17466308-Tunica Intima,
pubmed-meshheading:17466308-Vasoconstrictor Agents
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| pubmed:year |
2008
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| pubmed:articleTitle |
Interferon-beta attenuates angiotensin II-accelerated atherosclerosis and vascular remodeling in apolipoprotein E deficient mice.
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| pubmed:affiliation |
Department of Pharmacology and Immunology, Berlex Bioscience, 2600 Hilltop Drive, P.O. Box 4099, Richmond, CA 94806, USA. Le-Ning_Zhang@berlex.com
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| pubmed:publicationType |
Journal Article
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