Linked Life Data

17464546

Source:http://linkedlifedata.com/resource/pubmed/id/17464546

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2007-8-22
pubmed:abstractText
We previously performed a magnetic resonance imaging (MRI) parcellation study that showed smaller grey and white matter volumes of the temporal lobes and increased CSF volumes in the frontal and temporal lobe in men with schizophrenia. One question that arose from this earlier study was whether similar structural changes in the brain are found in a large group of schizophrenic patients consisting of both men and women. In the present study, MRI scans were acquired from 94 patients of both genders with schizophrenia and 101 healthy subjects. After the automatic segmentation of grey matter, white matter, and cerebrospinal fluid, the frontal, temporal, parietal, and occipital lobes were automatically parcellated according to the Talairach atlas. Compared with healthy subjects, schizophrenic patients showed significantly smaller volumes of grey matter in the temporal lobe and white matter in the frontal lobe. Schizophrenic patients had a greater CSF volume in the frontal and temporal lobes. These results suggest that volume reduction in the cerebrum is prominent in the frontal and temporal lobes in both men and women with schizophrenia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0940-1334
pubmed:author
pubmed:issnType
Print
pubmed:volume
257
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
304-7
pubmed:dateRevised
2009-5-11
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Frontal and temporal volume size of grey and white matter in patients with schizophrenia: an MRI parcellation study.
pubmed:affiliation
Department of Clinical Neuroscience, Human Brain Informatics, Karolinska Institutet, Stockholm 171-76, Sweden. okugawa@takii.kmu.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't