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rdf:type |
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lifeskim:mentions |
umls-concept:C0003209,
umls-concept:C0036679,
umls-concept:C0085979,
umls-concept:C0237868,
umls-concept:C0332120,
umls-concept:C0599946,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1858460,
umls-concept:C2350572,
umls-concept:C2911692
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pubmed:issue |
5
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pubmed:dateCreated |
2007-5-22
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pubmed:abstractText |
A previous study found that intracerebroventricular (ICV) infusion of 25 microg of alpha-MSH reduced the passive responses (crouched stance, eye-closing, piloerection) of guinea pig pups during a 3-h isolation in a novel environment. Because alpha-MSH has broad anti-inflammatory properties, the results suggested that proinflammatory factors play a role in mediating the behavior of isolated infants. The present study further investigated this possibility. In Experiment 1, injection of lipopolysacchride (LPS) increased the number of 60-s intervals in which pups expressed the same three responses during a 1-h test, and ICV infusion of alpha-MSH significantly reduced the effect of LPS on crouching and piloerection. In Experiment 2, the prostaglandin synthesis inhibitor indomethacin (10 mg/kg) reduced the number of 60-s intervals in which pups exhibited both crouching and the full suite of passive responses during a 3-h isolation in a novel environment. Together these results provide further support for the hypothesis that the passive behaviors exhibited during prolonged isolation are "stress-induced sickness behaviors" mediated by proinflammatory factors.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17462831-10371676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17462831-104324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17462831-10469524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17462831-10580315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17462831-10595426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17462831-10816650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17462831-10970676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17462831-11568877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17462831-12175599,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17462831-12851308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17462831-14643840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17462831-15059678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17462831-15464048,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17462831-15694227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17462831-15836907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17462831-15885777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17462831-16214237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17462831-1623564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17462831-2029641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17462831-2063478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17462831-2126980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17462831-2172935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17462831-3050629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17462831-4966515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17462831-7512342,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17462831-8434052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17462831-8556346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17462831-8748963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17462831-8822527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17462831-8873240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17462831-9138749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17462831-9450372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17462831-961122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17462831-9700679,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17462831-9813238
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0306-4530
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
32
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
508-15
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17462831-Animals,
pubmed-meshheading:17462831-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:17462831-Behavior, Animal,
pubmed-meshheading:17462831-Female,
pubmed-meshheading:17462831-Guinea Pigs,
pubmed-meshheading:17462831-Immobility Response, Tonic,
pubmed-meshheading:17462831-Indomethacin,
pubmed-meshheading:17462831-Inflammation Mediators,
pubmed-meshheading:17462831-Injections, Intraventricular,
pubmed-meshheading:17462831-Lipopolysaccharides,
pubmed-meshheading:17462831-Maternal Deprivation,
pubmed-meshheading:17462831-Sick Role,
pubmed-meshheading:17462831-Social Isolation,
pubmed-meshheading:17462831-Statistics, Nonparametric,
pubmed-meshheading:17462831-Stress, Psychological,
pubmed-meshheading:17462831-alpha-MSH
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pubmed:year |
2007
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pubmed:articleTitle |
Anti-inflammatory agents attenuate the passive responses of guinea pig pups: evidence for stress-induced sickness behavior during maternal separation.
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pubmed:affiliation |
Department of Psychology, Wright State University, Dayton, OH 45435, USA. michael.hennessy@wright.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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