Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2008-4-21
pubmed:abstractText
Cardiovascular disease is a major global cause of mortality, and its fundamental underlying substrate is atherosclerosis. Young and old patients have different risk factor profiles, clinical presentations, angiographic findings and prognosis. We performed a retrospective case-control study in a cohort (cases) of premature coronary disease (<or=45 years, n=200) compared with consecutive (controls) older patients (>45 years, n=200). The proportion of premature coronary disease in our geographic area was 9%. The average age of the case group was 41 and 64 years in controls (p<0.001). The male sex, though majority in both groups, was significantly more prevalent in the young group (92.5%) than in the older group (76.0%, p<0.001). The presence of smoking habit, hyperlipidemia and family history was significantly higher in the case group as well, with smoking habit being the most prevalent risk factor. In contrast, hypertension and diabetes were more frequent in controls. The number of affected vessels in cases was significantly less than the control group (1.4+/-0.8 vs. 1.7+/-0.9; p=0.013). Premature coronary disease affects predominantly the male sex and shows high prevalence of cardiovascular risk factors, mainly tobacco, hyperlipidemia, and family history of ischemic heart disease. In addition, it is characterised by a less extensive coronary atherosclerosis, mainly with the higher presence of single-vessel disease in contrast to older patients, as well as lower initial mortality.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1874-1754
pubmed:author
pubmed:issnType
Electronic
pubmed:day
7
pubmed:volume
126
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
127-9
pubmed:meshHeading
pubmed:year
2008
pubmed:articleTitle
Premature myocardial infarction: clinical profile and angiographic findings.
pubmed:publicationType
Letter, Comparative Study