rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
6
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pubmed:dateCreated |
2007-6-5
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pubmed:databankReference |
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pubmed:abstractText |
Activation of the Fanconi anemia (FA) DNA damage-response pathway results in the monoubiquitination of FANCD2, which is regulated by the nuclear FA core ubiquitin ligase complex. A FANCD2 protein sequence-based homology search facilitated the discovery of FANCI, a second monoubiquitinated component of the FA pathway. Biallelic mutations in the gene coding for this protein were found in cells from four FA patients, including an FA-I reference cell line.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
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pubmed:month |
Jun
|
pubmed:issn |
1545-9993
|
pubmed:author |
pubmed-author:AritaAdriana GAG,
pubmed-author:AuerbachArleen DAD,
pubmed-author:FreundMarcelM,
pubmed-author:HanenbergHelmutH,
pubmed-author:HuangTony TTT,
pubmed-author:LachFrancis PFP,
pubmed-author:LandersThomasT,
pubmed-author:NevelingKorneliaK,
pubmed-author:SimsAshley EAE,
pubmed-author:SimsRobert JRJ3rd,
pubmed-author:SpiteriElizabethE,
pubmed-author:WurmMelanieM
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pubmed:issnType |
Print
|
pubmed:volume |
14
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
564-7
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pubmed:meshHeading |
pubmed-meshheading:17460694-Amino Acid Sequence,
pubmed-meshheading:17460694-Base Sequence,
pubmed-meshheading:17460694-Blotting, Western,
pubmed-meshheading:17460694-Computational Biology,
pubmed-meshheading:17460694-DNA Repair,
pubmed-meshheading:17460694-Fanconi Anemia,
pubmed-meshheading:17460694-Fanconi Anemia Complementation Group D2 Protein,
pubmed-meshheading:17460694-Fanconi Anemia Complementation Group Proteins,
pubmed-meshheading:17460694-HeLa Cells,
pubmed-meshheading:17460694-Humans,
pubmed-meshheading:17460694-Immunoprecipitation,
pubmed-meshheading:17460694-Microscopy, Fluorescence,
pubmed-meshheading:17460694-Molecular Sequence Data,
pubmed-meshheading:17460694-Mutation,
pubmed-meshheading:17460694-Sequence Analysis, DNA,
pubmed-meshheading:17460694-Ubiquitination
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pubmed:year |
2007
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pubmed:articleTitle |
FANCI is a second monoubiquitinated member of the Fanconi anemia pathway.
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pubmed:affiliation |
Department of Biochemistry, New York University School of Medicine, New York, New York 10016, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|