Source:http://linkedlifedata.com/resource/pubmed/id/17460453
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2007-4-26
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| pubmed:abstractText |
"Carditis" (inflammation of the gastric cardiac mucosa) may be associated with gastroesophageal reflux disease (GERD), whereas other studies argue that Helicobacter pylori could play a significant role in the chronic cardiac damage. We examined prospectively histologic features of gastric cardia, esophagitis, and H. pylori status in 204 consecutive subjects with GERD symptoms (57.3% male, 42.7% female mean age 49.2 y) undergoing upper gastrointestinal endoscopy with multiple biopsies in the distal esophagus, cardiac region, and stomach. These were assessed for esophagitis landmarks [Ismail Beigi grading (g0-3)], gastritis, and H. pylori infection (Sydney classification). The average symptom duration was 10.8 months. Endoscopy showed no erosive disease in 54.5% patients, grade "A" esophagitis in 37.6%, "B" in 8%, and "C" in 1 case. Histologic examination disclosed g0 in 8.3% patients, g1 in 78.4%, g2 in 12.8%, and g3 in 1; analysis of the cardia showed oxyntic mucosa in 27.9% patients and chronic cardiac mucosa inflammation in 72.1%. Carditis was significantly related to macroscopic esophagitis (P=0.044) and heartburn score (P=0.001). H. pylori cardiac infection was present in 27.4% cases (73.2% associated with cardiac mucosa). Gastric H. pylori infection was demonstrated in 35% patients. H. pylori in the cardiac region was associated with gastric H. pylori infection (P=0.001) and with paucity of GERD symptoms (P=0.05). A good correlation between carditis and GERD, concerning symptoms and macroscopic esophagitis was found in this study. H. pylori-related carditis is likely to be differently compared with the GERD-related type.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
0147-5185
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| pubmed:author |
pubmed-author:BassottiGabrioG,
pubmed-author:CasaDomenico DellaDD,
pubmed-author:CengiaPaoloP,
pubmed-author:CestariRenzoR,
pubmed-author:DonatoFrancescoF,
pubmed-author:GambarottiMarcoM,
pubmed-author:GentaRobert MRM,
pubmed-author:MinelliLuigiL,
pubmed-author:MissaleGuidoG,
pubmed-author:PiraliFrancescoF,
pubmed-author:RossiElisaE,
pubmed-author:VillanacciVincenzoV
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| pubmed:issnType |
Print
|
| pubmed:volume |
31
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
706-10
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| pubmed:dateRevised |
2008-3-6
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| pubmed:meshHeading |
pubmed-meshheading:17460453-Adult,
pubmed-meshheading:17460453-Aged,
pubmed-meshheading:17460453-Aged, 80 and over,
pubmed-meshheading:17460453-Cardia,
pubmed-meshheading:17460453-Endoscopy, Gastrointestinal,
pubmed-meshheading:17460453-Esophagitis, Peptic,
pubmed-meshheading:17460453-Female,
pubmed-meshheading:17460453-Gastric Mucosa,
pubmed-meshheading:17460453-Gastroesophageal Reflux,
pubmed-meshheading:17460453-Heartburn,
pubmed-meshheading:17460453-Helicobacter Infections,
pubmed-meshheading:17460453-Helicobacter pylori,
pubmed-meshheading:17460453-Humans,
pubmed-meshheading:17460453-Male,
pubmed-meshheading:17460453-Middle Aged,
pubmed-meshheading:17460453-Prospective Studies,
pubmed-meshheading:17460453-Switzerland
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| pubmed:year |
2007
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| pubmed:articleTitle |
The pathology of gastric cardia: a prospective, endoscopic, and morphologic study.
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| pubmed:affiliation |
Surgical Endoscopy Unit, Department of Clinical and Experimental Medicine, University of Perugia School of Medicine, Italy.
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| pubmed:publicationType |
Journal Article
|