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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2007-4-26
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pubmed:abstractText |
To describe a sensitivity to light-induced damage associated with expression of a T17M mutant human rhodopsin (hT17M) transgene in mice, with the goal of minimizing retinal injury during the subretinal delivery of rAAV-mediated gene therapy.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0146-0404
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1942-51
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17460245-Animals,
pubmed-meshheading:17460245-Apoptosis,
pubmed-meshheading:17460245-Dependovirus,
pubmed-meshheading:17460245-Disease Models, Animal,
pubmed-meshheading:17460245-Electroretinography,
pubmed-meshheading:17460245-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:17460245-Female,
pubmed-meshheading:17460245-Gene Therapy,
pubmed-meshheading:17460245-Genes, Dominant,
pubmed-meshheading:17460245-In Situ Nick-End Labeling,
pubmed-meshheading:17460245-Light,
pubmed-meshheading:17460245-Male,
pubmed-meshheading:17460245-Mice,
pubmed-meshheading:17460245-Mice, Inbred C57BL,
pubmed-meshheading:17460245-Mice, Knockout,
pubmed-meshheading:17460245-Mice, Transgenic,
pubmed-meshheading:17460245-Photoreceptor Cells, Vertebrate,
pubmed-meshheading:17460245-Polymerase Chain Reaction,
pubmed-meshheading:17460245-Radiation Injuries, Experimental,
pubmed-meshheading:17460245-Retina,
pubmed-meshheading:17460245-Retinal Degeneration,
pubmed-meshheading:17460245-Rhodopsin,
pubmed-meshheading:17460245-Transgenes
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pubmed:year |
2007
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pubmed:articleTitle |
Increased sensitivity to light-induced damage in a mouse model of autosomal dominant retinal disease.
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pubmed:affiliation |
Department of Molecular Genetics, University of Florida, Gainesville, Florida 32610, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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