| pubmed-article:17459711 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17459711 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:17459711 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:17459711 | lifeskim:mentions | umls-concept:C1510827 | lld:lifeskim |
| pubmed-article:17459711 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:17459711 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:17459711 | pubmed:dateCreated | 2007-5-28 | lld:pubmed |
| pubmed-article:17459711 | pubmed:abstractText | A series of 7-substituted melatonin and 1-methylmelatonin analogues were prepared and tested against human and amphibian melatonin receptors. 7-Substituents reduced the agonist potency of all the analogues in the Xenopus laevis melanophore assay, 7-bromomelatonin (5d) and N-butanoyl 7-bromo-5-methoxytryptamine (5f) being the most active compounds, but both were 42-fold less potent than melatonin (1). Whereas all the analogues bind with lower affinity at the human MT(1) receptor than melatonin, 5d, 5f and N-propanoyl 7-bromo-5-methoxytryptamine (5e) show a similar binding affinity to melatonin at the MT(2) receptor and consequently show some MT(2) selectivity. These results suggest that the receptor pocket around C-7 favours binding by an electronegative group, suggesting an electropositive region in this area of the receptor. | lld:pubmed |
| pubmed-article:17459711 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17459711 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17459711 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17459711 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17459711 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17459711 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17459711 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17459711 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17459711 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17459711 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17459711 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:17459711 | pubmed:issn | 0968-0896 | lld:pubmed |
| pubmed-article:17459711 | pubmed:author | pubmed-author:SugdenDavidD | lld:pubmed |
| pubmed-article:17459711 | pubmed:author | pubmed-author:FrølundBenteB | lld:pubmed |
| pubmed-article:17459711 | pubmed:author | pubmed-author:TehMuy-TeckMT | lld:pubmed |
| pubmed-article:17459711 | pubmed:author | pubmed-author:FaustRüdigerR | lld:pubmed |
| pubmed-article:17459711 | pubmed:author | pubmed-author:GarrattPeter... | lld:pubmed |
| pubmed-article:17459711 | pubmed:author | pubmed-author:MadsenChristi... | lld:pubmed |
| pubmed-article:17459711 | pubmed:author | pubmed-author:DavidsonKathr... | lld:pubmed |
| pubmed-article:17459711 | pubmed:author | pubmed-author:PiccioVincent... | lld:pubmed |
| pubmed-article:17459711 | pubmed:author | pubmed-author:Trujillo... | lld:pubmed |
| pubmed-article:17459711 | pubmed:author | pubmed-author:StenstrømAneA | lld:pubmed |
| pubmed-article:17459711 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17459711 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:17459711 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:17459711 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17459711 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17459711 | pubmed:pagination | 4543-51 | lld:pubmed |
| pubmed-article:17459711 | pubmed:meshHeading | pubmed-meshheading:17459711... | lld:pubmed |
| pubmed-article:17459711 | pubmed:meshHeading | pubmed-meshheading:17459711... | lld:pubmed |
| pubmed-article:17459711 | pubmed:meshHeading | pubmed-meshheading:17459711... | lld:pubmed |
| pubmed-article:17459711 | pubmed:meshHeading | pubmed-meshheading:17459711... | lld:pubmed |
| pubmed-article:17459711 | pubmed:meshHeading | pubmed-meshheading:17459711... | lld:pubmed |
| pubmed-article:17459711 | pubmed:meshHeading | pubmed-meshheading:17459711... | lld:pubmed |
| pubmed-article:17459711 | pubmed:meshHeading | pubmed-meshheading:17459711... | lld:pubmed |
| pubmed-article:17459711 | pubmed:meshHeading | pubmed-meshheading:17459711... | lld:pubmed |
| pubmed-article:17459711 | pubmed:meshHeading | pubmed-meshheading:17459711... | lld:pubmed |
| pubmed-article:17459711 | pubmed:meshHeading | pubmed-meshheading:17459711... | lld:pubmed |
| pubmed-article:17459711 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17459711 | pubmed:articleTitle | 7-Substituted-melatonin and 7-substituted-1-methylmelatonin analogues: effect of substituents on potency and binding affinity. | lld:pubmed |
| pubmed-article:17459711 | pubmed:affiliation | Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, UK. | lld:pubmed |
| pubmed-article:17459711 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17459711 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:17459711 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17459711 | lld:pubmed |
