Linked Life Data

17458181

Source:http://linkedlifedata.com/resource/pubmed/id/17458181

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2007-4-26
pubmed:abstractText
The rising incidence of obesity, as a disorder of energy metabolism, has provoked a search for pharmacological agents that either increase energy expenditure or reduce food intake. The fatty acid oxidation pathway, and its rate-limiting enzyme carnitine palmitoyltransferase (CPT)-1 are potential targets for the treatment of obesity. The modulation of CPT-1 may simultaneously affect energy metabolism and food intake to aid in the management of obesity. Both the inhibition and enhancement of CPT-1 activity are currently under investigation as strategies for the treatment of obesity. In this review, key data on both sides of the 'CPT-1 activity balance' as they relate to obesity therapy are discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1472-4472
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
312-7
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Modulation of carnitine palmitoyltransferase-1 for the treatment of obesity.
pubmed:affiliation
The Johns Hopkins University School of Medicine, Department of Pathology, UMB BioPark, Building 1, 800 West Baltimore Street, Suite 150, Baltimore, MD 21201, USA. fkuhajda@jhmi.edu
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't