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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2007-5-14
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pubmed:abstractText |
Deficient healing after endovascular aneurysm repair with a stent-graft is thought to be related to pro-apoptotic environment in abdominal aortic aneurysms and inertness of graft materials. We developed a bioactive coating containing chondroitin-4-sulfate and assessed its potential to improve cell adhesion, viability and resistance to apoptosis on PET surfaces. Coatings of collagen type I and CS were prepared and characterized by DMMB, FT-IR, DSC, SEM and contact angle goniometry. Preliminary cell culture experiments with vascular smooth muscle cells showed increased adhesion and viability in serum-free medium on CS-coated surfaces compared to control PET films.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1616-5187
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
746-52
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pubmed:meshHeading |
pubmed-meshheading:17457946-Animals,
pubmed-meshheading:17457946-Aortic Aneurysm, Abdominal,
pubmed-meshheading:17457946-Apoptosis,
pubmed-meshheading:17457946-Blood Vessel Prosthesis,
pubmed-meshheading:17457946-Blood Vessels,
pubmed-meshheading:17457946-Cell Adhesion,
pubmed-meshheading:17457946-Cell Culture Techniques,
pubmed-meshheading:17457946-Cell Line,
pubmed-meshheading:17457946-Cell Survival,
pubmed-meshheading:17457946-Chondroitin Sulfates,
pubmed-meshheading:17457946-Coated Materials, Biocompatible,
pubmed-meshheading:17457946-Collagen Type I,
pubmed-meshheading:17457946-Humans,
pubmed-meshheading:17457946-Materials Testing,
pubmed-meshheading:17457946-Methylene Blue,
pubmed-meshheading:17457946-Muscle, Smooth, Vascular,
pubmed-meshheading:17457946-Polyethylene Terephthalates,
pubmed-meshheading:17457946-Rats,
pubmed-meshheading:17457946-Spectroscopy, Fourier Transform Infrared,
pubmed-meshheading:17457946-Stents,
pubmed-meshheading:17457946-Wound Healing
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pubmed:year |
2007
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pubmed:articleTitle |
Chondroitin-4-sulfate: a bioactive macromolecule to foster vascular healing around stent-grafts after endovascular aneurysm repair.
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pubmed:affiliation |
Centre de Recherche, Centre Hospitalier de l'Université de Montréal, 1560 Sherbrooke Est, Montréal, QC, Canada H2L 4M1.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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