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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2007-7-26
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pubmed:abstractText |
The transcription factor Nurr1 (NR4A2) has been found to play a critical role in the development of midbrain dopaminergic neurons. Nurr1 heterozygous (+/-) male and female mice expressing 35-40% of normal levels of Nurr1 were generated and examined in animal models related to symptoms of schizophrenia. The Nurr1 (+/-) mice displayed hyperactivity in a novel environment, which persisted after administration of the dopamine-mimetic amphetamine and the N-methyl-D-aspartate receptor antagonist phencyclidine. The Nurr1 (+/-) mice were deficient in the retention of emotional memory and showed an enhanced response to swim stress. In addition, Nurr1 (+/-) male mice displayed a reduced dopamine turnover in the striatum and an enhanced dopamine turnover in the prefrontal cortex, while female mice showed an opposite pattern. These results show that Nurr1 (+/-) mice display a pattern of behaviors indicative of potential relevance for symptoms of schizophrenia combined with a gender-specific abnormal dopamine transmission in the striatum and prefrontal cortex, respectively. This suggests that the Nurr1 mutant mouse may be a potential animal model for studies on some of the behavioral and molecular mechanisms underlying schizophrenia.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1359-4184
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
756-66
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17457314-Adaptation, Psychological,
pubmed-meshheading:17457314-Analysis of Variance,
pubmed-meshheading:17457314-Animals,
pubmed-meshheading:17457314-Behavior, Animal,
pubmed-meshheading:17457314-DNA-Binding Proteins,
pubmed-meshheading:17457314-Disease Models, Animal,
pubmed-meshheading:17457314-Dopamine,
pubmed-meshheading:17457314-Exploratory Behavior,
pubmed-meshheading:17457314-Female,
pubmed-meshheading:17457314-Heterozygote,
pubmed-meshheading:17457314-Hyperkinesis,
pubmed-meshheading:17457314-Male,
pubmed-meshheading:17457314-Mice,
pubmed-meshheading:17457314-Mice, Inbred C57BL,
pubmed-meshheading:17457314-Mice, Knockout,
pubmed-meshheading:17457314-Motor Activity,
pubmed-meshheading:17457314-Neostriatum,
pubmed-meshheading:17457314-Nerve Tissue Proteins,
pubmed-meshheading:17457314-Nuclear Receptor Subfamily 4, Group A, Member 2,
pubmed-meshheading:17457314-Prefrontal Cortex,
pubmed-meshheading:17457314-Schizophrenia,
pubmed-meshheading:17457314-Sex Factors,
pubmed-meshheading:17457314-Statistics, Nonparametric,
pubmed-meshheading:17457314-Stress, Psychological,
pubmed-meshheading:17457314-Transcription Factors
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pubmed:year |
2007
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pubmed:articleTitle |
Adult mice with reduced Nurr1 expression: an animal model for schizophrenia.
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pubmed:affiliation |
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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