| pubmed-article:17456199 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17456199 | lifeskim:mentions | umls-concept:C0521026 | lld:lifeskim |
| pubmed-article:17456199 | lifeskim:mentions | umls-concept:C0022671 | lld:lifeskim |
| pubmed-article:17456199 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:17456199 | lifeskim:mentions | umls-concept:C0085295 | lld:lifeskim |
| pubmed-article:17456199 | lifeskim:mentions | umls-concept:C0450127 | lld:lifeskim |
| pubmed-article:17456199 | lifeskim:mentions | umls-concept:C1882714 | lld:lifeskim |
| pubmed-article:17456199 | lifeskim:mentions | umls-concept:C0038952 | lld:lifeskim |
| pubmed-article:17456199 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:17456199 | pubmed:dateCreated | 2007-4-25 | lld:pubmed |
| pubmed-article:17456199 | pubmed:abstractText | Interleukin-10 (IL-10) is a pleiotropic cytokine that plays a pivotal role in the regulation of immune responses. Hence, we evaluated the effects of a recombinant adeno-associated viral vector 1 (rAAV1) encoding rat IL-10 (rAAV1-IL-10) in a rat model of kidney allograft rejection. Dark Agouti rat kidneys were transplanted into Wistar-Furth (WF) rats 8 weeks following a single intramuscular administration of either rAAV1-IL-10 or rAAV1-green fluorescence protein (GFP). Isografts (WF-WF) served as an additional experimental control. Both allograft and isograft recipients received daily cyclosporine (10 mg/kg) for 14 days after transplantation. Serum IL-10 levels increased at 8, 12 and 16 weeks following vector administration in rAAV1-IL-10-treated animals, but not in rAAV1-GFP and isograft groups. rAAV1-IL-10 treatment resulted in lower BUN and creatinine levels (p<0.001), as well as increased allograft survival rates from 22% to 90%. Allograft histological abnormalities were significantly attenuated in the rAAV1-IL-10-treated rats compared with those of rAAV1-GFP controls. Serum levels of proinflammatory cytokines such as growth-related oncogene were also significantly higher in the rAAV1-GFP group than in the rAAV1-IL-10 group. These data suggest delivery of IL-10 using a rAAV1 vector improves renal function and prolongs graft survival in a rat model of kidney transplant rejection. | lld:pubmed |
| pubmed-article:17456199 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17456199 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17456199 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17456199 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17456199 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17456199 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17456199 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17456199 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17456199 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17456199 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17456199 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17456199 | pubmed:month | May | lld:pubmed |
| pubmed-article:17456199 | pubmed:issn | 1600-6135 | lld:pubmed |
| pubmed-article:17456199 | pubmed:author | pubmed-author:ChenSS | lld:pubmed |
| pubmed-article:17456199 | pubmed:author | pubmed-author:TisherC CCC | lld:pubmed |
| pubmed-article:17456199 | pubmed:author | pubmed-author:JosephRR | lld:pubmed |
| pubmed-article:17456199 | pubmed:author | pubmed-author:AtkinsonM AMA | lld:pubmed |
| pubmed-article:17456199 | pubmed:author | pubmed-author:ChenBB | lld:pubmed |
| pubmed-article:17456199 | pubmed:author | pubmed-author:AgarwalAA | lld:pubmed |
| pubmed-article:17456199 | pubmed:author | pubmed-author:FlotteT RTR | lld:pubmed |
| pubmed-article:17456199 | pubmed:author | pubmed-author:GeorgeJ FJF | lld:pubmed |
| pubmed-article:17456199 | pubmed:author | pubmed-author:Campbell-Thom... | lld:pubmed |
| pubmed-article:17456199 | pubmed:author | pubmed-author:WasserfallC... | lld:pubmed |
| pubmed-article:17456199 | pubmed:author | pubmed-author:KapturczakM... | lld:pubmed |
| pubmed-article:17456199 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17456199 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:17456199 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17456199 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17456199 | pubmed:pagination | 1112-20 | lld:pubmed |
| pubmed-article:17456199 | pubmed:dateRevised | 2007-12-3 | lld:pubmed |
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| pubmed-article:17456199 | pubmed:meshHeading | pubmed-meshheading:17456199... | lld:pubmed |
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| pubmed-article:17456199 | pubmed:meshHeading | pubmed-meshheading:17456199... | lld:pubmed |
| pubmed-article:17456199 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17456199 | pubmed:articleTitle | Adeno-associated viral vector-mediated interleukin-10 prolongs allograft survival in a rat kidney transplantation model. | lld:pubmed |
| pubmed-article:17456199 | pubmed:affiliation | Department of Medicine, Nephrology Research and Training Center, University of Alabama at Birmingham, Birmingham, Alabama, USA. | lld:pubmed |
| pubmed-article:17456199 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17456199 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17456199 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17456199 | lld:pubmed |
