Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2007-4-24
pubmed:abstractText
Gliadin digestion-resistant peptides are harmful in coeliac disease (CD), and initiate an autoimmune reaction that cause a cascade of symptoms. The role of the endogenous prolyl oligopeptidase (POP) is still not clear, and its activity over gliadin immunoactive peptides has not been fully established. Our objective was therefore to determine the endogenous POP protein level, tissue distribution and total activity in normal and CD epithelia, to evaluate tissue peptidase activity over gliadin peptides, and compare this with activities of mammalian POP and rat intestinal extracts.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0036-5521
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
562-71
pubmed:meshHeading
pubmed-meshheading:17454876-Animals, pubmed-meshheading:17454876-Autoimmunity, pubmed-meshheading:17454876-Biopsy, pubmed-meshheading:17454876-Blotting, Western, pubmed-meshheading:17454876-Celiac Disease, pubmed-meshheading:17454876-Chromatography, High Pressure Liquid, pubmed-meshheading:17454876-DNA, pubmed-meshheading:17454876-Digestion, pubmed-meshheading:17454876-Disease Models, Animal, pubmed-meshheading:17454876-Endoscopy, Gastrointestinal, pubmed-meshheading:17454876-Epithelium, pubmed-meshheading:17454876-Gene Expression, pubmed-meshheading:17454876-Gliadin, pubmed-meshheading:17454876-Humans, pubmed-meshheading:17454876-Immunohistochemistry, pubmed-meshheading:17454876-Intestinal Mucosa, pubmed-meshheading:17454876-Male, pubmed-meshheading:17454876-Mass Spectrometry, pubmed-meshheading:17454876-Rats, pubmed-meshheading:17454876-Rats, Wistar, pubmed-meshheading:17454876-Serine Endopeptidases, pubmed-meshheading:17454876-Swine
pubmed:year
2007
pubmed:articleTitle
Deficient activity of mammalian prolyl oligopeptidase on the immunoactive peptide digestion in coeliac disease.
pubmed:affiliation
Centro de Investigación Príncipe Felipe, Valencia, Spain. garciaho@cipf.es
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't