Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2007-4-24
pubmed:abstractText
Cartilage engineered from chondrocytes requires a scaffold to keep the cells in the cartilage defect and to act as a support for inducing hyaline cartilage formation on occasion. In this study, we developed a novel three-dimensional special scaffold in combination with a controlled release of bFGF, which provided structural support and stimulated repair. Gelatin microspheres loaded with bFGF (GM-bFGF) showed a fast release at the initial phase (28.23%) and the ultimate accumulated release was 92.9% by day 14. Three-dimensional gelatin-chondroitin-hyaluronan hybrid scaffolds seeded with cultured autologous chondrocytes were transplanted into the defects in rabbit knees and analyzed histologically at 12 and 24 weeks after the operation. Our findings showed that the defects were filled with smooth, shiny white cartilaginous tissue macroscopically and hyaline-like cartilage histologically 24 weeks postoperatively. The present study implied the great potential of the novel scaffold with GM-bFGF as a new way to promote the retention of chondrocytes and it might serve as a desirable cartilaginous tissue scaffolds to enhance the chondrogenesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0265-2048
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
163-74
pubmed:dateRevised
2009-7-21
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Cartilage regeneration using a novel gelatin-chondroitin-hyaluronan hybrid scaffold containing bFGF-impregnated microspheres.
pubmed:affiliation
Department of Oral and Maxillofacial Surgery, College of Stomatology, Fourth Military Medical University, Xi'an 710032, PR China.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't